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10.1016/j.isci.2022.103967 http://scihub22266oqcxt.onion/10.1016/j.isci.2022.103967 35224468!8863311!35224468     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2022 ; 25 (3): 103967 Nephropedia Template TP {{tp|p=35224468|t=2022. Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses |pdf=|usr=}}{{35224468}} gab.com Text Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=35224468 #FOAvip The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of the CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies. Twit Text FOAVip Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=35224468 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35224468 #FOAvip English Wikipedia <ref>{{Cite pmid|35224468}}</ref> Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses #MMPMID35224468 Wang ZN; Yang XS; Sun J; Zhao JC; Zhong NS; Tang XX iScience 2022[Mar]; 25 (3): 103967 PMID35224468show ga The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of the CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies. äMulti-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dyna(epmc).pdf DeepDyve Pubget Overpricing