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10.3389/fmicb.2022.840911 http://scihub22266oqcxt.onion/10.3389/fmicb.2022.840911 35222346!8866975!35222346     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Microbiol 2022 ; 13 (ä): 840911 Nephropedia Template TP {{tp|p=35222346|t=2022. The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity |pdf=|usr=}}{{35222346}} gab.com Text The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity JO: Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=35222346 #FOAvip Viruses play a key role in explaining the pathogenesis of various autoimmune disorders, whose underlying principle is defined by the activation of autoreactive T-cells. In many cases, T-cells escape self-tolerance due to the failure in encountering certain MHC-I self-peptide complexes at substantial levels, whose peptides remain invisible from the immune system. Over the years, contribution of unstable defective ribosomal products (DRiPs) in immunosurveillance has gained prominence. A class of unstable products emerge from non-canonical translation and processing of unannotated mammalian and viral ORFs and their peptides are cryptic in nature. Indeed, high throughput sequencing and proteomics have revealed that a substantial portion of our genomes comprise of non-canonical ORFs, whose generation is significantly modulated during disease. Many of these ORFs comprise short ORFs (sORFs) and upstream ORFs (uORFs) that resemble DRiPs and may hence be preferentially presented. Here, we discuss how such products, normally "hidden" from the immune system, become abundant in viral infections activating autoimmune T-cells, by discussing their emerging role in infection and disease. Finally, we provide a perspective on how these mechanisms can explain several autoimmune disorders in the wake of the COVID-19 pandemic. Twit Text FOAVip The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity ????Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=35222346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35222346 #FOAvip English Wikipedia <ref>{{Cite pmid|35222346}}</ref> The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity #MMPMID35222346 Lodha M; Erhard F; Dolken L; Prusty BK Front Microbiol 2022[]; 13 (ä): 840911 PMID35222346show ga Viruses play a key role in explaining the pathogenesis of various autoimmune disorders, whose underlying principle is defined by the activation of autoreactive T-cells. In many cases, T-cells escape self-tolerance due to the failure in encountering certain MHC-I self-peptide complexes at substantial levels, whose peptides remain invisible from the immune system. Over the years, contribution of unstable defective ribosomal products (DRiPs) in immunosurveillance has gained prominence. A class of unstable products emerge from non-canonical translation and processing of unannotated mammalian and viral ORFs and their peptides are cryptic in nature. Indeed, high throughput sequencing and proteomics have revealed that a substantial portion of our genomes comprise of non-canonical ORFs, whose generation is significantly modulated during disease. Many of these ORFs comprise short ORFs (sORFs) and upstream ORFs (uORFs) that resemble DRiPs and may hence be preferentially presented. Here, we discuss how such products, normally "hidden" from the immune system, become abundant in viral infections activating autoimmune T-cells, by discussing their emerging role in infection and disease. Finally, we provide a perspective on how these mechanisms can explain several autoimmune disorders in the wake of the COVID-19 pandemic. äThe Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoi(epmc).pdf DeepDyve Pubget Overpricing