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10.1016/j.medine.2020.10.007

http://scihub22266oqcxt.onion/10.1016/j.medine.2020.10.007
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35221002!8867537!35221002
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suck abstract from ncbi


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pmid35221002      Med+Intensiva+(Engl+Ed) 2022 ; 46 (3): 132-139
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  • High serum nitrates levels in non-survivor COVID-19 patients #MMPMID35221002
  • Lorente L; Gomez-Bernal F; Martin MM; Navarro-Gonzalvez JA; Argueso M; Perez A; Ramos-Gomez L; Sole-Violan J; Marcos Y Ramos JA; Ojeda N; Jimenez A
  • Med Intensiva (Engl Ed) 2022[Mar]; 46 (3): 132-139 PMID35221002show ga
  • OBJECTIVE: Higher blood nitrate and nitrite levels have been found in coronavirus disease 2019 (COVID-19) patients than in healthy subjects. The present study explores the potential association between serum nitrate levels and mortality in COVID-19 patients. DESIGN: A prospective observation study was carried out. SETTING: Eight Intensive Care Units (ICUs) from 6 hospitals in the Canary Islands (Spain). PATIENTS: COVID-19 patients admitted to the ICU. INTERVENTIONS: Determination of serum nitrate levels at ICU admission. MAIN VARIABLE OF INTEREST: Mortality at 30 days. RESULTS: Non-surviving (n=11) compared to surviving patients (n=42) showed higher APACHE-II (p<0.001) and SOFA scores (p=0.004), and higher serum nitrate levels (p=0.001). Logistic regression analyses showed serum nitrate levels to be associated to 30-day mortality after controlling for SOFA (OR=1.021; 95%CI=1.006-1.036; p=0.01) or APACHE-II (OR=1.023; 95%CI=1.006-1.041; p=0.01). There were no differences in the area under the curve (AUC) for mortality prediction by serum nitrate levels (AUC=83%; 95%CI=73-92%; p<0.001), APACHE II (AUC=85%; 95%CI=75-96%; p<0.001) and SOFA (AUC=78%; 95%CI=63-92%; p=0.005) based on the DeLong method. The Kaplan-Meier analysis found patients with serum nitrates levels>68.4mumol/l to have a higher mortality rate (hazard ratio=138.8; 95%CI=22.3-863.9; p<0.001). CONCLUSIONS: The main novel finding was the association between serum nitrate levels and mortality in COVID-19 patients controlling for the SOFA or APACHE-II scores, though larger studies are needed to confirm this observation.
  • |*COVID-19[MESH]
  • |*Nitrates[MESH]
  • |APACHE[MESH]
  • |Humans[MESH]
  • |Prospective Studies[MESH]


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