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10.3390/v14020189 http://scihub22266oqcxt.onion/10.3390/v14020189 35215785!8878863!35215785     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35215785.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Viruses 2022 ; 14 (2): ä Nephropedia Template TP {{tp|p=35215785|t=2022. Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection |pdf=|usr=}}{{35215785}} gab.com Text Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35215785 #FOAvip SARS-CoV-2, a member of the coronavirus family, is the causative agent of the COVID-19 pandemic. Currently, there is still an urgent need in developing an efficient therapeutic intervention. In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice. We demonstrate here that early Poly(I:C) treatment acts synergistically with SARS-CoV-2 to induce an intense, immediate and transient upregulation of innate immunity-related genes in lungs. This effect is accompanied by viral load reduction, lung and brain cytokine storms prevention and increased levels of macrophages and NK cells, resulting in 83% mice survival, concomitantly with long-term immunization. Thus, priming the lung innate immunity by Poly(I:C) or alike may provide an immediate, efficient and safe protective measure against SARS-CoV-2 infection. Twit Text FOAVip Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35215785 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35215785 #FOAvip English Wikipedia <ref>{{Cite pmid|35215785}}</ref> Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection #MMPMID35215785 Tamir H; Melamed S; Erez N; Politi B; Yahalom-Ronen Y; Achdout H; Lazar S; Gutman H; Avraham R; Weiss S; Paran N; Israely T Viruses 2022[Jan]; 14 (2): ä PMID35215785show ga SARS-CoV-2, a member of the coronavirus family, is the causative agent of the COVID-19 pandemic. Currently, there is still an urgent need in developing an efficient therapeutic intervention. In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice. We demonstrate here that early Poly(I:C) treatment acts synergistically with SARS-CoV-2 to induce an intense, immediate and transient upregulation of innate immunity-related genes in lungs. This effect is accompanied by viral load reduction, lung and brain cytokine storms prevention and increased levels of macrophages and NK cells, resulting in 83% mice survival, concomitantly with long-term immunization. Thus, priming the lung innate immunity by Poly(I:C) or alike may provide an immediate, efficient and safe protective measure against SARS-CoV-2 infection. |*Immunity, Innate[MESH] |Angiotensin-Converting Enzyme 2/genetics/immunology[MESH] |Animals[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology/*prevention & control[MESH] |Cytokine Release Syndrome/immunology/prevention & control[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Lung/immunology/virology[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Poly I-C/*immunology/*therapeutic use[MESH] |SARS-CoV-2/*drug effects/immunology[MESH] |Toll-Like Receptor 3/*agonists/immunology[MESH]Induction of Innate Immune Response by TLR3 Agonist Protects Mice agai(epmc).pdf DeepDyve Pubget Overpricing