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10.3390/v14020189

http://scihub22266oqcxt.onion/10.3390/v14020189
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35215785!8878863!35215785
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suck abstract from ncbi


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pmid35215785      Viruses 2022 ; 14 (2): ä
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  • Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection #MMPMID35215785
  • Tamir H; Melamed S; Erez N; Politi B; Yahalom-Ronen Y; Achdout H; Lazar S; Gutman H; Avraham R; Weiss S; Paran N; Israely T
  • Viruses 2022[Jan]; 14 (2): ä PMID35215785show ga
  • SARS-CoV-2, a member of the coronavirus family, is the causative agent of the COVID-19 pandemic. Currently, there is still an urgent need in developing an efficient therapeutic intervention. In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice. We demonstrate here that early Poly(I:C) treatment acts synergistically with SARS-CoV-2 to induce an intense, immediate and transient upregulation of innate immunity-related genes in lungs. This effect is accompanied by viral load reduction, lung and brain cytokine storms prevention and increased levels of macrophages and NK cells, resulting in 83% mice survival, concomitantly with long-term immunization. Thus, priming the lung innate immunity by Poly(I:C) or alike may provide an immediate, efficient and safe protective measure against SARS-CoV-2 infection.
  • |*Immunity, Innate[MESH]
  • |Angiotensin-Converting Enzyme 2/genetics/immunology[MESH]
  • |Animals[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*immunology/*prevention & control[MESH]
  • |Cytokine Release Syndrome/immunology/prevention & control[MESH]
  • |Disease Models, Animal[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/immunology/virology[MESH]
  • |Mice[MESH]
  • |Mice, Transgenic[MESH]
  • |Poly I-C/*immunology/*therapeutic use[MESH]
  • |SARS-CoV-2/*drug effects/immunology[MESH]
  • |Toll-Like Receptor 3/*agonists/immunology[MESH]


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