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pmid3521443      Ann+Clin+Res 1986 ; 18 (2): 88-92
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  • Comparison of low doses of hydrochlorothiazide plus amiloride and hydrochlorothiazide alone in hypertension in elderly patients #MMPMID3521443
  • Salmela PI; Juustila H; Kinnunen O; Koistinen P
  • Ann Clin Res 1986[]; 18 (2): 88-92 PMID3521443show ga
  • A randomised, double-blind study comparing 25 mg of hydrochlorothiazide plus 2.5 mg of amiloride with 25 mg of hydrochlorothiazide alone was conducted in 40 elderly patients with mild to moderate hypertension. After 8 weeks of treatment, the target blood pressure, supine diastolic blood pressure less than 90 mm Hg, was obtained in 73% of the hydrochlorothiazide plus amiloride treated patients (n = 17) and in 41% of the hydrochlorothiazide treated patients (n = 19; p less than 0.05). However, there was no statistically significant difference in blood pressure reduction between the 2 groups. Four patients dropped out, 3 of them due to side-effects. Serum potassium and magnesium concentrations were reduced in the hydrochlorothiazide group and serum sodium concentration in the hydrochlorothiazide plus amiloride group. Our results suggest that in elderly hypertensive subjects, a higher proportion of patients could be managed with the low dose hydrochlorothiazide plus amiloride regimen than with the low dose hydrochlorothiazide regimen.
  • |Aged[MESH]
  • |Amiloride/*administration & dosage/adverse effects[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Double-Blind Method[MESH]
  • |Drug Combinations[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydrochlorothiazide/*administration & dosage/adverse effects[MESH]
  • |Hypertension/*drug therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Random Allocation[MESH]


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