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10.1096/fj.202101521R http://scihub22266oqcxt.onion/10.1096/fj.202101521R 35199397!9111296!35199397     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35199397&cmd=llinks): Failed to open stream: HTTP request failed! 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The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17 |pdf=|usr=}}{{35199397}} gab.com Text The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17 JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=35199397 #FOAvip The transmembrane protease angiotensin converting enzyme 2 (ACE2) is a protective regulator within the renin angiotensin system and additionally represents the cellular receptor for SARS-CoV. The release of soluble ACE2 (sACE2) from the cell surface is hence believed to be a crucial part of its (patho)physiological functions, as both, ACE2 protease activity and SARS-CoV binding ability, are transferred from the cell membrane to body fluids. Yet, the molecular sources of sACE2 are still not completely investigated. In this study, we show different sources and prerequisites for the release of sACE2 from the cell membrane. By using inhibitors as well as CRISPR/Cas9-derived cells, we demonstrated that, in addition to the metalloprotease ADAM17, also ADAM10 is an important novel shedding protease of ACE2. Moreover, we observed that ACE2 can also be released in extracellular vesicles. The degree of either ADAM10- or ADAM17-mediated ACE2 shedding is dependent on stimulatory conditions and on the expression level of the pro-inflammatory ADAM17 regulator iRhom2. Finally, by using structural analysis and in vitro verification, we determined for the first time that the susceptibility to ADAM10- and ADAM17-mediated shedding is mediated by the collectrin-like part of ACE2. Overall, our findings give novel insights into sACE2 release by several independent molecular mechanisms. Twit Text FOAVip The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17 ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=35199397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35199397 #FOAvip English Wikipedia <ref>{{Cite pmid|35199397}}</ref> The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17 #MMPMID35199397 Niehues RV; Wozniak J; Wiersch F; Lilienthal E; Tacken N; Schumertl T; Garbers C; Ludwig A; Dusterhoft S FASEB J 2022[Mar]; 36 (3): e22234 PMID35199397show ga The transmembrane protease angiotensin converting enzyme 2 (ACE2) is a protective regulator within the renin angiotensin system and additionally represents the cellular receptor for SARS-CoV. The release of soluble ACE2 (sACE2) from the cell surface is hence believed to be a crucial part of its (patho)physiological functions, as both, ACE2 protease activity and SARS-CoV binding ability, are transferred from the cell membrane to body fluids. Yet, the molecular sources of sACE2 are still not completely investigated. In this study, we show different sources and prerequisites for the release of sACE2 from the cell membrane. By using inhibitors as well as CRISPR/Cas9-derived cells, we demonstrated that, in addition to the metalloprotease ADAM17, also ADAM10 is an important novel shedding protease of ACE2. Moreover, we observed that ACE2 can also be released in extracellular vesicles. The degree of either ADAM10- or ADAM17-mediated ACE2 shedding is dependent on stimulatory conditions and on the expression level of the pro-inflammatory ADAM17 regulator iRhom2. Finally, by using structural analysis and in vitro verification, we determined for the first time that the susceptibility to ADAM10- and ADAM17-mediated shedding is mediated by the collectrin-like part of ACE2. Overall, our findings give novel insights into sACE2 release by several independent molecular mechanisms. |ADAM10 Protein/genetics/*metabolism[MESH] |ADAM17 Protein/genetics/*metabolism[MESH] |Amyloid Precursor Protein Secretases/genetics/*metabolism[MESH] |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Clustered Regularly Interspaced Short Palindromic Repeats[MESH] |Extracellular Vesicles/genetics/*metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Intracellular Signaling Peptides and Proteins/genetics/metabolism[MESH] |Membrane Glycoproteins/genetics/*metabolism[MESH] |Membrane Proteins/genetics/*metabolism[MESH] |SARS-CoV-2[MESH]The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is she(epmc).pdf DeepDyve Pubget Overpricing