Genetic Engineering Systems to Study Human Viral Pathogens from the Coronaviridae Family #MMPMID35194246
Galkin SO; Anisenko AN; Shadrina OA; Gottikh MB
Mol Biol 2022[]; 56 (1): 72-89 PMID35194246show ga
The COVID-19 pandemic caused by the previously unknown SARS-CoV-2 Betacoronavirus made it extremely important to develop simple and safe cellular systems which allow manipulation of the viral genome and high-throughput screening of its potential inhibitors. In this review, we made an attempt at summarizing the currently existing data on genetic engineering systems used to study not only SARS-CoV-2, but also other viruses from the Coronaviridae family. In addition, the review covers the basic knowledge about the structure and the life cycle of coronaviruses.