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10.1073/pnas.2116435119

http://scihub22266oqcxt.onion/10.1073/pnas.2116435119
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35193979!8892305!35193979
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suck abstract from ncbi


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pmid35193979      Proc+Natl+Acad+Sci+U+S+A 2022 ; 119 (9): ä
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  • The major genetic risk factor for severe COVID-19 is associated with protection against HIV #MMPMID35193979
  • Zeberg H
  • Proc Natl Acad Sci U S A 2022[Mar]; 119 (9): ä PMID35193979show ga
  • There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, Nature 600, 472-477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Paabo, Nature 587, 610-612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an approximately 27% lower risk of HIV infection.
  • |*HIV-1[MESH]
  • |*Haplotypes[MESH]
  • |*SARS-CoV-2[MESH]
  • |COVID-19/*genetics/prevention & control[MESH]
  • |Chromosomes, Human, Pair 3/*genetics[MESH]
  • |HIV Infections/*genetics/prevention & control[MESH]
  • |Humans[MESH]
  • |Patient Acuity[MESH]


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