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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2022 ; 119 (9): ä Nephropedia Template TP
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The major genetic risk factor for severe COVID-19 is associated with protection against HIV #MMPMID35193979
Zeberg H
Proc Natl Acad Sci U S A 2022[Mar]; 119 (9): ä PMID35193979show ga
There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, Nature 600, 472-477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Paabo, Nature 587, 610-612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an approximately 27% lower risk of HIV infection.