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10.1002/anie.202201432 http://scihub22266oqcxt.onion/10.1002/anie.202201432 35191576!9074024!35191576     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2022 ; 61 (18): e202201432 Nephropedia Template TP {{tp|p=35191576|t=2022. The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View |pdf=|usr=}}{{35191576}} gab.com Text The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=35191576 #FOAvip The interaction of the SARS CoV2 spike glycoprotein with two sialic acid-containing trisaccharides (alpha2,3 and alpha2,6 sialyl N-acetyllactosamine) has been demonstrated by NMR. The NMR-based distinction between the signals of those sialic acids in the glycans covalently attached to the spike protein and those belonging to the exogenous alpha2,3 and alpha2,6 sialyl N-acetyllactosamine ligands has been achieved by synthesizing uniformly (13) C-labelled trisaccharides at the sialic acid and galactose moieties. STD-(1) H,(13) C-HSQC NMR experiments elegantly demonstrate the direct interaction of the sialic acid residues of both trisaccharides with additional participation of the galactose moieties, especially for the alpha2,3-linked analogue. Additional experiments with the spike protein in the presence of a specific antibody for the N-terminal domain and with the isolated receptor binding and N-terminal domains of the spike protein unambiguously show that the sialic acid binding site is located at the N-terminal domain. Twit Text FOAVip The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=35191576 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35191576 #FOAvip English Wikipedia <ref>{{Cite pmid|35191576}}</ref> The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View #MMPMID35191576 Unione L; Moure MJ; Lenza MP; Oyenarte I; Ereno-Orbea J; Arda A; Jimenez-Barbero J Angew Chem Int Ed Engl 2022[Apr]; 61 (18): e202201432 PMID35191576show ga The interaction of the SARS CoV2 spike glycoprotein with two sialic acid-containing trisaccharides (alpha2,3 and alpha2,6 sialyl N-acetyllactosamine) has been demonstrated by NMR. The NMR-based distinction between the signals of those sialic acids in the glycans covalently attached to the spike protein and those belonging to the exogenous alpha2,3 and alpha2,6 sialyl N-acetyllactosamine ligands has been achieved by synthesizing uniformly (13) C-labelled trisaccharides at the sialic acid and galactose moieties. STD-(1) H,(13) C-HSQC NMR experiments elegantly demonstrate the direct interaction of the sialic acid residues of both trisaccharides with additional participation of the galactose moieties, especially for the alpha2,3-linked analogue. Additional experiments with the spike protein in the presence of a specific antibody for the N-terminal domain and with the isolated receptor binding and N-terminal domains of the spike protein unambiguously show that the sialic acid binding site is located at the N-terminal domain. |*COVID-19[MESH] |*Spike Glycoprotein, Coronavirus/chemistry[MESH] |Binding Sites[MESH] |Galactose[MESH] |Humans[MESH] |N-Acetylneuraminic Acid/chemistry[MESH] |SARS-CoV-2[MESH] |Sialic Acids/chemistry[MESH]The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Aci(epmc).pdf DeepDyve Pubget Overpricing