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10.1016/j.jcrc.2022.154010

http://scihub22266oqcxt.onion/10.1016/j.jcrc.2022.154010
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suck abstract from ncbi


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pmid35183892      J+Crit+Care 2022 ; 69 (ä): 154010
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  • The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infection #MMPMID35183892
  • Vigstedt M; Soe-Jensen P; Bestle MH; Clausen NE; Kristiansen KT; Lange T; Stensballe J; Perner A; Johansson PI
  • J Crit Care 2022[Jun]; 69 (ä): 154010 PMID35183892show ga
  • BACKGROUND: In a pilot study, we found a significant reduction in mean daily sequential organ failure assessment score in mechanically ventilated patients with COVID-19 who received prostacyclin, compared to placebo. We here investigate the effect on biomarkers of endothelial activation and damage. METHODS: Post-hoc study of a randomized controlled trial in adult patients with confirmed SARS-CoV-2 infection, mechanically ventilated, with soluble thrombomodulin (sTM) plasma levels >4 ng/mL. Patients received prostacyclin infusion (1 ng/kg/min) or placebo. Blood samples were collected at baseline and 24 h. RESULTS: Eighty patients were randomized (41 prostacyclin, 39 placebo). The median changes in syndecan-1 plasma levels at 24 h were -3.95 (IQR: -21.1 to 2.71) ng/mL in the prostacyclin group vs. 3.06 (IQR: -8.73 to 20.5) ng/mL in the placebo group (difference of the medians: -7.01 [95% CI: -22.3 to -0.231] ng/mL, corresponding to -3% [95% CI: -11% to 0%], p = 0.04). Changes in plasma levels of sTM, PECAM-1, p-selectin, and CD40L did not differ significantly between groups. CONCLUSIONS: Prostacyclin infusion, compared to placebo, resulted in a measurable decrease in endothelial glycocalyx shedding (syndecan-1) at 24 h, suggesting a protective effect on the endothelium, which may be related to the observed reduction in organ failure.
  • |*COVID-19[MESH]
  • |*Epoprostenol/pharmacology/therapeutic use[MESH]
  • |Adult[MESH]
  • |Biomarkers[MESH]
  • |Endothelium, Vascular[MESH]
  • |Humans[MESH]
  • |Pilot Projects[MESH]
  • |Respiration, Artificial[MESH]
  • |SARS-CoV-2[MESH]


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