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10.1016/j.isci.2022.103784 http://scihub22266oqcxt.onion/10.1016/j.isci.2022.103784 35169687!8829776!35169687     free     free     free       iScience 2022 ; 25 (2): 103784 Nephropedia Template TP {{tp|p=35169687|t=2022. Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration |pdf=|usr=}}{{35169687}} gab.com Text Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=35169687 #FOAvip Zebrafish regenerate fin rays following amputation through epimorphic regeneration, a process that has been proposed to involve the epithelial-to-mesenchymal transition (EMT). We performed single-cell RNA sequencing (scRNA-seq) to elucidate osteoblastic transcriptional programs during zebrafish caudal fin regeneration. We show that osteoprogenitors are enriched with components associated with EMT and its reverse, mesenchymal-to-epithelial transition (MET), and provide evidence that the EMT markers cdh11 and twist2 are co-expressed in dedifferentiating cells at the amputation stump at 1 dpa, and in differentiating osteoblastic cells in the regenerate, the latter of which are enriched in EMT signatures. We also show that esrp1, a regulator of alternative splicing in epithelial cells that is associated with MET, is expressed in a subset of osteoprogenitors during outgrowth. This study provides a single cell resource for the study of osteoblastic cells during zebrafish fin regeneration, and supports the contribution of MET- and EMT-associated components to this process. Twit Text FOAVip Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=35169687 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35169687 #FOAvip English Wikipedia <ref>{{Cite pmid|35169687}}</ref> Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration #MMPMID35169687 Tang WJ; Watson CJ; Olmstead T; Allan CH; Kwon RY iScience 2022[Feb]; 25 (2): 103784 PMID35169687show ga Zebrafish regenerate fin rays following amputation through epimorphic regeneration, a process that has been proposed to involve the epithelial-to-mesenchymal transition (EMT). We performed single-cell RNA sequencing (scRNA-seq) to elucidate osteoblastic transcriptional programs during zebrafish caudal fin regeneration. We show that osteoprogenitors are enriched with components associated with EMT and its reverse, mesenchymal-to-epithelial transition (MET), and provide evidence that the EMT markers cdh11 and twist2 are co-expressed in dedifferentiating cells at the amputation stump at 1 dpa, and in differentiating osteoblastic cells in the regenerate, the latter of which are enriched in EMT signatures. We also show that esrp1, a regulator of alternative splicing in epithelial cells that is associated with MET, is expressed in a subset of osteoprogenitors during outgrowth. This study provides a single cell resource for the study of osteoblastic cells during zebrafish fin regeneration, and supports the contribution of MET- and EMT-associated components to this process. ?Single-cell resolution of MET- and EMT-like programs in osteoblasts du(epmc).pdf DeepDyve Pubget Overpricing