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10.1371/journal.pone.0263995

http://scihub22266oqcxt.onion/10.1371/journal.pone.0263995
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35167610!8846540!35167610
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suck abstract from ncbi


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pmid35167610      PLoS+One 2022 ; 17 (2): e0263995
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  • Predictors of life-threatening complications in relatively lower-risk patients hospitalized with COVID-19 #MMPMID35167610
  • Gonzalez CJ; Hogan CJ; Rajan M; Wells MT; Safford MM; Pinheiro LC; Ghosh AK; Choi JJ; Burchenal CA; Shah PD; Shapiro MF
  • PLoS One 2022[]; 17 (2): e0263995 PMID35167610show ga
  • Older individuals with chronic health conditions are at highest risk of adverse clinical outcomes from COVID-19, but there is widespread belief that risk to younger, relatively lower-risk individuals is negligible. We assessed the rate and predictors of life-threatening complications among relatively lower-risk adults hospitalized with COVID-19. Of 3766 adults hospitalized with COVID-19 to three hospitals in New York City from March to May 2020, 963 were relatively lower-risk based on absence of preexisting health conditions. Multivariable logistic regression models examined in-hospital development of life-threatening complications (major medical events, intubation, or death). Covariates included age, sex, race/ethnicity, hypertension, weight, insurance type, and area-level sociodemographic factors (poverty, crowdedness, and limited English proficiency). In individuals >/=55 years old (n = 522), 33.3% experienced a life-threatening complication, 17.4% were intubated, and 22.6% died. Among those <55 years (n = 441), 15.0% experienced a life-threatening complication, 11.1% were intubated, and 5.9% died. In multivariable analyses among those >/=55 years, age (OR 1.03 [95%CI 1.01-1.06]), male sex (OR 1.72 [95%CI 1.14-2.64]), being publicly insured (versus commercial insurance: Medicare, OR 2.02 [95%CI 1.22-3.38], Medicaid, OR 1.87 [95%CI 1.10-3.20]) and living in areas with relatively high limited English proficiency (highest versus lowest quartile: OR 3.50 [95%CI 1.74-7.13]) predicted life-threatening complications. In those <55 years, no sociodemographic factors significantly predicted life-threatening complications. A substantial proportion of relatively lower-risk patients hospitalized with COVID-19 experienced life-threatening complications and more than 1 in 20 died. Public messaging needs to effectively convey that relatively lower-risk individuals are still at risk of serious complications.
  • |Age Factors[MESH]
  • |COVID-19/complications/ethnology/*pathology/virology[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Hypertension/*complications[MESH]
  • |Length of Stay[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New York City[MESH]
  • |Proportional Hazards Models[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Severity of Illness Index[MESH]


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