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10.3390/ijms23031583 http://scihub22266oqcxt.onion/10.3390/ijms23031583 35163504!8835897!35163504     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2022 ; 23 (3): ä Nephropedia Template TP {{tp|p=35163504|t=2022. Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19 |pdf=|usr=}}{{35163504}} gab.com Text Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=35163504 #FOAvip (1) Background: In COVID-19 survivors there is an increased prevalence of pulmonary fibrosis of which the underlying molecular mechanisms are poorly understood; (2) Methods: In this multicentric study, n = 12 patients who succumbed to COVID-19 due to progressive respiratory failure were assigned to an early and late group (death within </=7 and >7 days of hospitalization, respectively) and compared to n = 11 healthy controls; mRNA and protein expression as well as biological pathway analysis were performed to gain insights into the evolution of pulmonary fibrogenesis in COVID-19; (3) Results: Median duration of hospitalization until death was 3 (IQR25-75, 3-3.75) and 14 (12.5-14) days in the early and late group, respectively. Fifty-eight out of 770 analyzed genes showed a significantly altered expression signature in COVID-19 compared to controls in a time-dependent manner. The entire study group showed an increased expression of BST2 and IL1R1, independent of hospitalization time. In the early group there was increased activity of inflammation-related genes and pathways, while fibrosis-related genes (particularly PDGFRB) and pathways dominated in the late group; (4) Conclusions: After the first week of hospitalization, there is a shift from pro-inflammatory to fibrogenic activity in severe COVID-19. IL1R1 and PDGFRB may serve as potential therapeutic targets in future studies. Twit Text FOAVip Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=35163504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35163504 #FOAvip English Wikipedia <ref>{{Cite pmid|35163504}}</ref> Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19 #MMPMID35163504 Kamp JC; Neubert L; Ackermann M; Stark H; Werlein C; Fuge J; Haverich A; Tzankov A; Steinestel K; Friemann J; Boor P; Junker K; Hoeper MM; Welte T; Laenger F; Kuehnel MP; Jonigk DD Int J Mol Sci 2022[Jan]; 23 (3): ä PMID35163504show ga (1) Background: In COVID-19 survivors there is an increased prevalence of pulmonary fibrosis of which the underlying molecular mechanisms are poorly understood; (2) Methods: In this multicentric study, n = 12 patients who succumbed to COVID-19 due to progressive respiratory failure were assigned to an early and late group (death within 7 days of hospitalization, respectively) and compared to n = 11 healthy controls; mRNA and protein expression as well as biological pathway analysis were performed to gain insights into the evolution of pulmonary fibrogenesis in COVID-19; (3) Results: Median duration of hospitalization until death was 3 (IQR25-75, 3-3.75) and 14 (12.5-14) days in the early and late group, respectively. Fifty-eight out of 770 analyzed genes showed a significantly altered expression signature in COVID-19 compared to controls in a time-dependent manner. The entire study group showed an increased expression of BST2 and IL1R1, independent of hospitalization time. In the early group there was increased activity of inflammation-related genes and pathways, while fibrosis-related genes (particularly PDGFRB) and pathways dominated in the late group; (4) Conclusions: After the first week of hospitalization, there is a shift from pro-inflammatory to fibrogenic activity in severe COVID-19. IL1R1 and PDGFRB may serve as potential therapeutic targets in future studies. |Aged[MESH] |COVID-19/*genetics/*metabolism/mortality[MESH] |Female[MESH] |Hospital Mortality/trends[MESH] |Hospitalization[MESH] |Humans[MESH] |Lung/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Pulmonary Fibrosis/metabolism/*pathology[MESH] |Respiratory Insufficiency/pathology[MESH]Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing