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Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) Protein #MMPMID35159253
Mjokane N; Maliehe M; Folorunso OS; Ogundeji AO; Gcilitshana OMN; Albertyn J; Pohl CH; Sebolai OM
Cells 2022[Jan]; 11 (3): ä PMID35159253show ga
In this contribution, we report on the possibility that cryptococcal protease(s) could activate the SARS-CoV-2 spike (S) protein. The S protein is documented to have a unique four-amino-acid sequence (underlined, SPRRAR downward arrowS) at the interface between the S1 and S2 sites, that serves as a cleavage site for the human protease, furin. We compared the biochemical efficiency of cryptococcal protease(s) and furin to mediate the proteolytic cleavage of the S1/S2 site in a fluorogenic peptide. We show that cryptococcal protease(s) processes this site in a manner comparable to the efficiency of furin (p > 0.581). We conclude the paper by discussing the impact of these findings in the context of a SARS-CoV-2 disease manifesting while there is an underlying cryptococcal infection.