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10.3389/fimmu.2021.801410 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.801410 35154077!8835351!35154077     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35154077&cmd=llinks): Failed to open stream: HTTP request failed! 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Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19 |pdf=|usr=}}{{35154077}} gab.com Text Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35154077 #FOAvip Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease (coronavirus disease 2019, COVID-19) that may develop into a systemic disease with immunosuppression and death in its severe form. Myeloid-derived suppressive cells (MDSCs) are inhibitory cells that contribute to immunosuppression in patients with cancer and infection. Increased levels of MDSCs have been found in COVID-19 patients, although their role in the pathogenesis of severe COVID-19 has not been clarified. For this reason, we raised the question whether MDSCs could be useful in the follow-up of patients with severe COVID-19 in the intensive care unit (ICU). Thus, we monitored the immunological cells, including MDSCs, in 80 patients admitted into the ICU. After 1, 2, and 3 weeks, we examined for a possible association with mortality (40 patients). Although the basal levels of circulating MDSCs did not discriminate between the two groups of patients, the last measurement before the endpoint (death or ICU discharge) showed that patients discharged alive from the ICU had lower levels of granulocytic MDSCs (G-MDSCs), higher levels of activated lymphocytes, and lower levels of exhausted lymphocytes compared with patients who had a bad evolution (death). In conclusion, a steady increase of G-MDSCs during the follow-up of patients with severe COVID-19 was found in those who eventually died. Twit Text FOAVip Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35154077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35154077 #FOAvip English Wikipedia <ref>{{Cite pmid|35154077}}</ref> Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19 #MMPMID35154077 Jimenez-Cortegana C; Sanchez-Jimenez F; Perez-Perez A; Alvarez N; Sousa A; Canton-Bulnes L; Vilarino-Garcia T; Fuentes S; Martin S; Jimenez M; Leon-Justel A; de la Cruz-Merino L; Garnacho-Montero J; Sanchez-Margalet V Front Immunol 2021[]; 12 (ä): 801410 PMID35154077show ga Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease (coronavirus disease 2019, COVID-19) that may develop into a systemic disease with immunosuppression and death in its severe form. Myeloid-derived suppressive cells (MDSCs) are inhibitory cells that contribute to immunosuppression in patients with cancer and infection. Increased levels of MDSCs have been found in COVID-19 patients, although their role in the pathogenesis of severe COVID-19 has not been clarified. For this reason, we raised the question whether MDSCs could be useful in the follow-up of patients with severe COVID-19 in the intensive care unit (ICU). Thus, we monitored the immunological cells, including MDSCs, in 80 patients admitted into the ICU. After 1, 2, and 3 weeks, we examined for a possible association with mortality (40 patients). Although the basal levels of circulating MDSCs did not discriminate between the two groups of patients, the last measurement before the endpoint (death or ICU discharge) showed that patients discharged alive from the ICU had lower levels of granulocytic MDSCs (G-MDSCs), higher levels of activated lymphocytes, and lower levels of exhausted lymphocytes compared with patients who had a bad evolution (death). In conclusion, a steady increase of G-MDSCs during the follow-up of patients with severe COVID-19 was found in those who eventually died. |Aged[MESH] |COVID-19/*mortality/pathology[MESH] |Comorbidity[MESH] |Critical Care[MESH] |Female[MESH] |Granulocytes/cytology/*immunology[MESH] |Humans[MESH] |Immunocompromised Host/immunology[MESH] |Lymphocyte Activation/immunology[MESH] |Lymphocyte Count[MESH] |Lymphocyte Subsets/cytology/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Myeloid-Derived Suppressor Cells/cytology/*immunology[MESH] |Prospective Studies[MESH] |SARS-CoV-2/immunology[MESH] |Severity of Illness Index[MESH]Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a G(epmc).pdf DeepDyve Pubget Overpricing