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10.1016/j.ejmech.2022.114175 http://scihub22266oqcxt.onion/10.1016/j.ejmech.2022.114175 35151223!8813210!35151223     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Med+Chem 2022 ; 232 (ä): 114175 Nephropedia Template TP {{tp|p=35151223|t=2022. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy |pdf=|usr=}}{{35151223}} gab.com Text Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy JO: Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=35151223 #FOAvip oxidative stress is caused by an abundant generation of reactive oxygen species, associated to a diminished capacity of the endogenous systems of the organism to counteract them. Activation of pro-oxidative pathways and boosting of inflammatory cytokines are always encountered in viral infections, including SARS-CoV-2. So, the importance of counteracting cytokine storm in COVID-19 pathology is highly important, to hamper the immunogenic damage of the endothelium and alveolar membranes. Antioxidants prevent oxidative processes, by impeding radical species generation. It has been proved that vitamin intake lowers oxidative stress markers, alleviates cytokine storm and has a potential role in reducing disease severity, by lowering pro-inflammatory cytokines, hampering hyperinflammation and organ failure. For the approached compounds, direct antiviral roles are also discussed in this review, as these activities encompass secretion of antiviral peptides, modulation of angiotensin-converting enzyme 2 receptor expression and interaction with spike protein, inactivation of furin protease, or inhibition of pathogen replication by nucleic acid impairment induction. Vitamin administration results in beneficial effects. Nevertheless, timing, dosage and mutual influences of these micronutrients should be carefullly regarded. Twit Text FOAVip Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy ????Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=35151223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35151223 #FOAvip English Wikipedia <ref>{{Cite pmid|35151223}}</ref> Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy #MMPMID35151223 Pisoschi AM; Pop A; Iordache F; Stanca L; Geicu OI; Bilteanu L; Serban AI Eur J Med Chem 2022[Mar]; 232 (ä): 114175 PMID35151223show ga oxidative stress is caused by an abundant generation of reactive oxygen species, associated to a diminished capacity of the endogenous systems of the organism to counteract them. Activation of pro-oxidative pathways and boosting of inflammatory cytokines are always encountered in viral infections, including SARS-CoV-2. So, the importance of counteracting cytokine storm in COVID-19 pathology is highly important, to hamper the immunogenic damage of the endothelium and alveolar membranes. Antioxidants prevent oxidative processes, by impeding radical species generation. It has been proved that vitamin intake lowers oxidative stress markers, alleviates cytokine storm and has a potential role in reducing disease severity, by lowering pro-inflammatory cytokines, hampering hyperinflammation and organ failure. For the approached compounds, direct antiviral roles are also discussed in this review, as these activities encompass secretion of antiviral peptides, modulation of angiotensin-converting enzyme 2 receptor expression and interaction with spike protein, inactivation of furin protease, or inhibition of pathogen replication by nucleic acid impairment induction. Vitamin administration results in beneficial effects. Nevertheless, timing, dosage and mutual influences of these micronutrients should be carefullly regarded. |*Antioxidants/pharmacology/therapeutic use[MESH] |*COVID-19 Drug Treatment[MESH] |Anti-Inflammatory Agents[MESH] |Humans[MESH] |SARS-CoV-2[MESH]Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins (epmc).pdf DeepDyve Pubget Overpricing