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10.1016/j.jbc.2022.101710 http://scihub22266oqcxt.onion/10.1016/j.jbc.2022.101710 35150743!8828381!35150743     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2022 ; 298 (3): 101710 Nephropedia Template TP {{tp|p=35150743|t=2022. Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2 |pdf=|usr=}}{{35150743}} gab.com Text Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2 JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=35150743 #FOAvip Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is broadly accepted that SARS-CoV-2 utilizes its spike protein to recognize the extracellular domain of angiotensin-converting enzyme 2 (ACE2) to enter cells for viral infection. However, other mechanisms of SARS-CoV-2 cell entry may occur. We show quantitatively that the SARS-CoV-2 spike protein also binds to the extracellular domain of broadly expressed integrin alpha5beta1 with an affinity comparable to that of SARS-CoV-2 binding to ACE2. More importantly, we provide direct evidence that such binding promotes the internalization of SARS-CoV-2 into non-ACE2 cells in a manner critically dependent upon the activation of the integrin. Our data demonstrate an alternative pathway for the cell entry of SARS-CoV-2, suggesting that upon initial ACE2-mediated invasion of the virus in the respiratory system, which is known to trigger an immune response and secretion of cytokines to activate integrin, the integrin-mediated cell invasion of SARS-CoV-2 into the respiratory system and other organs becomes effective, thereby promoting further infection and progression of COVID-19. Twit Text FOAVip Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2 ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=35150743 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35150743 #FOAvip English Wikipedia <ref>{{Cite pmid|35150743}}</ref> Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2 #MMPMID35150743 Liu J; Lu F; Chen Y; Plow E; Qin J J Biol Chem 2022[Mar]; 298 (3): 101710 PMID35150743show ga Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is broadly accepted that SARS-CoV-2 utilizes its spike protein to recognize the extracellular domain of angiotensin-converting enzyme 2 (ACE2) to enter cells for viral infection. However, other mechanisms of SARS-CoV-2 cell entry may occur. We show quantitatively that the SARS-CoV-2 spike protein also binds to the extracellular domain of broadly expressed integrin alpha5beta1 with an affinity comparable to that of SARS-CoV-2 binding to ACE2. More importantly, we provide direct evidence that such binding promotes the internalization of SARS-CoV-2 into non-ACE2 cells in a manner critically dependent upon the activation of the integrin. Our data demonstrate an alternative pathway for the cell entry of SARS-CoV-2, suggesting that upon initial ACE2-mediated invasion of the virus in the respiratory system, which is known to trigger an immune response and secretion of cytokines to activate integrin, the integrin-mediated cell invasion of SARS-CoV-2 into the respiratory system and other organs becomes effective, thereby promoting further infection and progression of COVID-19. |*COVID-19/metabolism/virology[MESH] |*SARS-CoV-2/metabolism/physiology[MESH] |*Spike Glycoprotein, Coronavirus/metabolism[MESH] |*Virus Internalization[MESH] |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |Humans[MESH] |Integrins/metabolism[MESH]Integrin mediates cell entry of the SARS-CoV-2 virus independent of ce(epmc).pdf DeepDyve Pubget Overpricing