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10.1126/sciimmunol.abf2846 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abf2846 35148199!8991457!35148199     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2022 ; 7 (68): eabf2846 Nephropedia Template TP {{tp|p=35148199|t=2022. SLAMF7 engagement superactivates macrophages in acute and chronic inflammation |pdf=|usr=}}{{35148199}} gab.com Text SLAMF7 engagement superactivates macrophages in acute and chronic inflammation JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35148199 #FOAvip Macrophages regulate protective immune responses to infectious microbes, but aberrant macrophage activation frequently drives pathological inflammation. To identify regulators of vigorous macrophage activation, we analyzed RNA-seq data from synovial macrophages and identified SLAMF7 as a receptor associated with a superactivated macrophage state in rheumatoid arthritis. We implicated IFN-gamma as a key regulator of SLAMF7 expression and engaging SLAMF7 drove a strong wave of inflammatory cytokine expression. Induction of TNF-alpha after SLAMF7 engagement amplified inflammation through an autocrine signaling loop. We observed SLAMF7-induced gene programs not only in macrophages from rheumatoid arthritis patients but also in gut macrophages from patients with active Crohn's disease and in lung macrophages from patients with severe COVID-19. This suggests a central role for SLAMF7 in macrophage superactivation with broad implications in human disease pathology. Twit Text FOAVip SLAMF7 engagement superactivates macrophages in acute and chronic inflammation ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35148199 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35148199 #FOAvip English Wikipedia <ref>{{Cite pmid|35148199}}</ref> SLAMF7 engagement superactivates macrophages in acute and chronic inflammation #MMPMID35148199 Simmons DP; Nguyen HN; Gomez-Rivas E; Jeong Y; Jonsson AH; Chen AF; Lange JK; Dyer GS; Blazar P; Earp BE; Coblyn JS; Massarotti EM; Sparks JA; Todd DJ; Rao DA; Kim EY; Brenner MB Sci Immunol 2022[Feb]; 7 (68): eabf2846 PMID35148199show ga Macrophages regulate protective immune responses to infectious microbes, but aberrant macrophage activation frequently drives pathological inflammation. To identify regulators of vigorous macrophage activation, we analyzed RNA-seq data from synovial macrophages and identified SLAMF7 as a receptor associated with a superactivated macrophage state in rheumatoid arthritis. We implicated IFN-gamma as a key regulator of SLAMF7 expression and engaging SLAMF7 drove a strong wave of inflammatory cytokine expression. Induction of TNF-alpha after SLAMF7 engagement amplified inflammation through an autocrine signaling loop. We observed SLAMF7-induced gene programs not only in macrophages from rheumatoid arthritis patients but also in gut macrophages from patients with active Crohn's disease and in lung macrophages from patients with severe COVID-19. This suggests a central role for SLAMF7 in macrophage superactivation with broad implications in human disease pathology. |Acute Disease[MESH] |Adult[MESH] |Arthritis, Rheumatoid/genetics/immunology/metabolism[MESH] |COVID-19/genetics/immunology/metabolism/virology[MESH] |Cells, Cultured[MESH] |Chronic Disease[MESH] |Crohn Disease/genetics/immunology/metabolism[MESH] |Female[MESH] |Humans[MESH] |Inflammation/genetics/*immunology/metabolism[MESH] |Macrophage Activation/genetics/*immunology[MESH] |RNA-Seq/methods[MESH] |Reverse Transcriptase Polymerase Chain Reaction/methods[MESH] |SARS-CoV-2/immunology/physiology[MESH] |Signaling Lymphocytic Activation Molecule Family/genetics/*immunology/metabolism[MESH] |Single-Cell Analysis/methods[MESH] |Synovial Membrane/immunology/metabolism/pathology[MESH]SLAMF7 engagement superactivates macrophages in acute and chronic infl(epmc).pdf DeepDyve Pubget Overpricing