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10.3389/fcimb.2021.781968 http://scihub22266oqcxt.onion/10.3389/fcimb.2021.781968 35141167!8819187!35141167     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35141167&cmd=llinks): Failed to open stream: HTTP request failed! 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Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome |pdf=|usr=}}{{35141167}} gab.com Text Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=35141167 #FOAvip BACKGROUND: The upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited. OBJECTIVE: Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity. METHODS: Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19. RESULTS: URT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium_unclassified.ASV0002, consistently decreased as COVID-19 severity increased. CONCLUSIONS: We observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity. Twit Text FOAVip Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=35141167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35141167 #FOAvip English Wikipedia <ref>{{Cite pmid|35141167}}</ref> Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome #MMPMID35141167 Shilts MH; Rosas-Salazar C; Strickland BA; Kimura KS; Asad M; Sehanobish E; Freeman MH; Wessinger BC; Gupta V; Brown HM; Boone HH; Patel V; Barbi M; Bottalico D; O'Neill M; Akbar N; Rajagopala SV; Mallal S; Phillips E; Turner JH; Jerschow E; Das SR Front Cell Infect Microbiol 2021[]; 11 (ä): 781968 PMID35141167show ga BACKGROUND: The upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited. OBJECTIVE: Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity. METHODS: Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19. RESULTS: URT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium_unclassified.ASV0002, consistently decreased as COVID-19 severity increased. CONCLUSIONS: We observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity. |*COVID-19[MESH] |*Microbiota[MESH] |Adult[MESH] |Bacteria[MESH] |Humans[MESH] |Respiratory System[MESH]Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract (epmc).pdf DeepDyve Pubget Overpricing