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10.1172/JCI157124 http://scihub22266oqcxt.onion/10.1172/JCI157124 35139037!8970672!35139037     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2022 ; 132 (7): ä Nephropedia Template TP {{tp|p=35139037|t=2022. Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2 |pdf=|usr=}}{{35139037}} gab.com Text Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2 JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=35139037 #FOAvip BackgroundAlthough recent epidemiological data suggest that pneumococci may contribute to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in patients with coronavirus disease 2019 (COVID-19) during hospitalization have been reported infrequently. This apparent contradiction may be explained by interactions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pneumococci in the upper airway, resulting in the escape of SARS-CoV-2 from protective host immune responses.MethodsHere, we investigated the relationship of these 2 respiratory pathogens in 2 distinct cohorts of health care workers with asymptomatic or mildly symptomatic SARS-CoV-2 infection identified by systematic screening and patients with moderate to severe disease who presented to the hospital. We assessed the effect of coinfection on host antibody, cellular, and inflammatory responses to the virus.ResultsIn both cohorts, pneumococcal colonization was associated with diminished antiviral immune responses, which primarily affected mucosal IgA levels among individuals with mild or asymptomatic infection and cellular memory responses in infected patients.ConclusionOur findings suggest that S. pneumoniae impair host immunity to SARS-CoV-2 and raise the question of whether pneumococcal carriage also enables immune escape of other respiratory viruses and facilitates reinfection.Trial registrationISRCTN89159899 (FASTER study) and ClinicalTrials.gov NCT03502291 (LAIV study). Twit Text FOAVip Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2 ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=35139037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35139037 #FOAvip English Wikipedia <ref>{{Cite pmid|35139037}}</ref> Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2 #MMPMID35139037 Mitsi E; Reine J; Urban BC; Solorzano C; Nikolaou E; Hyder-Wright AD; Pojar S; Howard A; Hitchins L; Glynn S; Farrar MC; Liatsikos K; Collins AM; Walker NF; Hill HC; German EL; Cheliotis KS; Byrne RL; Williams CT; Cubas-Atienzar AI; Fletcher TE; Adams ER; Draper SJ; Pulido D; Beavon R; Theilacker C; Begier E; Jodar L; Gessner BD; Ferreira DM J Clin Invest 2022[Apr]; 132 (7): ä PMID35139037show ga BackgroundAlthough recent epidemiological data suggest that pneumococci may contribute to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in patients with coronavirus disease 2019 (COVID-19) during hospitalization have been reported infrequently. This apparent contradiction may be explained by interactions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pneumococci in the upper airway, resulting in the escape of SARS-CoV-2 from protective host immune responses.MethodsHere, we investigated the relationship of these 2 respiratory pathogens in 2 distinct cohorts of health care workers with asymptomatic or mildly symptomatic SARS-CoV-2 infection identified by systematic screening and patients with moderate to severe disease who presented to the hospital. We assessed the effect of coinfection on host antibody, cellular, and inflammatory responses to the virus.ResultsIn both cohorts, pneumococcal colonization was associated with diminished antiviral immune responses, which primarily affected mucosal IgA levels among individuals with mild or asymptomatic infection and cellular memory responses in infected patients.ConclusionOur findings suggest that S. pneumoniae impair host immunity to SARS-CoV-2 and raise the question of whether pneumococcal carriage also enables immune escape of other respiratory viruses and facilitates reinfection.Trial registrationISRCTN89159899 (FASTER study) and ClinicalTrials.gov NCT03502291 (LAIV study). |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Health Personnel[MESH] |Humans[MESH] |Immunity[MESH]Streptococcus pneumoniae colonization associates with impaired adaptiv(epmc).pdf DeepDyve Pubget Overpricing