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  • Determinants of suboptimal immune recovery among a Chinese Yi ethnicity population with sustained HIV suppression #MMPMID35135485
  • Chen L; Liu CH; Kang S; Du L; Ma F; Li C; Bai L; Li H; Tang H
  • BMC Infect Dis 2022[Feb]; 22 (1): 137 PMID35135485show ga
  • OBJECTIVES: Despite sustained viral suppression with effective antiretroviral therapy (ART), HIV-infected patients with suboptimal immune recovery are still at high risk of both non-AIDS-related and AIDS-related events. The aim of this study was to investigate determinants potentially associated with suboptimal CD4 + T cell count recovery during free ART with sustained viral suppression among an HIV-infected Yi ethnicity population in Liangshan Prefecture, an area in China with high HIV prevalence. METHODS: This retrospective study included HIV-infected Yi adults (>/= 18 years and baseline CD4 + T cell count less than 500 cells/muL) for whom ART supported by National Free Antiretroviral Treatment Program was initiated between January 2015 and December 2018 in Zhaojue County, Liangshan Prefecture. Virological suppression (viral load < 50 copies/mL) was achieved within 12 months after ART initiation, and sustained virological suppression was maintained. Multivariate log-binomial regression analysis was used to assess determinants of suboptimal immune recovery. RESULTS: There were 140 female and 137 male patients in this study, with a mean age of 36.57 +/- 7.63 years. Most of the Yi patients were infected through IDU (48.7%) or heterosexual contact (49.8%), and the anti-HCV antibody prevalence was high (43.7%, 121/277). Of the 277 patients with a mean ART duration of 3.77 +/- 1.21 years, complete immune recovery occurred in only 32.9%. The baseline CD4 + T cell count in patients with suboptimal and intermediate immune recovery was 248.64 +/- 108.10 and 288.59 +/- 108.86 cells/muL, respectively, which was much lower than the baseline 320.02 +/- 123.65 cells/muL in patients who achieved complete immune recovery (p < 0.001). Multivariable analysis demonstrated that low pre-ART CD4 + cell count and coinfection with HCV were associated with immune recovery of the HIV patients. CONCLUSIONS: Our study suggests that for HIV-infected Yi patients in Liangshan Prefecture, prompt ART initiation after diagnosis of HIV infection should be applied, and curative HCV treatment should be given to patients with HCV/HIV coinfection to improve the immunological effectiveness of ART. Trial registration None.
  • |*HIV Infections/drug therapy/epidemiology[MESH]
  • |Adult[MESH]
  • |Anti-Retroviral Agents/therapeutic use[MESH]
  • |Antiretroviral Therapy, Highly Active[MESH]
  • |CD4 Lymphocyte Count[MESH]
  • |Ethnicity[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Retrospective Studies[MESH]
  • |Viral Load[MESH]

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  • suck abstract from ncbi

    137 1.22 2022