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10.1186/s12879-022-07113-y http://scihub22266oqcxt.onion/10.1186/s12879-022-07113-y 35135485!8827152!35135485     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35135485&cmd=llinks): Failed to open stream: HTTP request failed! 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Determinants of suboptimal immune recovery among a Chinese Yi ethnicity population with sustained HIV suppression |pdf=|usr=}}{{35135485}} gab.com Text Determinants of suboptimal immune recovery among a Chinese Yi ethnicity population with sustained HIV suppression JO: BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=35135485 #FOAvip OBJECTIVES: Despite sustained viral suppression with effective antiretroviral therapy (ART), HIV-infected patients with suboptimal immune recovery are still at high risk of both non-AIDS-related and AIDS-related events. The aim of this study was to investigate determinants potentially associated with suboptimal CD4 + T cell count recovery during free ART with sustained viral suppression among an HIV-infected Yi ethnicity population in Liangshan Prefecture, an area in China with high HIV prevalence. METHODS: This retrospective study included HIV-infected Yi adults (>/= 18 years and baseline CD4 + T cell count less than 500 cells/muL) for whom ART supported by National Free Antiretroviral Treatment Program was initiated between January 2015 and December 2018 in Zhaojue County, Liangshan Prefecture. Virological suppression (viral load < 50 copies/mL) was achieved within 12 months after ART initiation, and sustained virological suppression was maintained. Multivariate log-binomial regression analysis was used to assess determinants of suboptimal immune recovery. RESULTS: There were 140 female and 137 male patients in this study, with a mean age of 36.57 +/- 7.63 years. Most of the Yi patients were infected through IDU (48.7%) or heterosexual contact (49.8%), and the anti-HCV antibody prevalence was high (43.7%, 121/277). Of the 277 patients with a mean ART duration of 3.77 +/- 1.21 years, complete immune recovery occurred in only 32.9%. The baseline CD4 + T cell count in patients with suboptimal and intermediate immune recovery was 248.64 +/- 108.10 and 288.59 +/- 108.86 cells/muL, respectively, which was much lower than the baseline 320.02 +/- 123.65 cells/muL in patients who achieved complete immune recovery (p < 0.001). Multivariable analysis demonstrated that low pre-ART CD4 + cell count and coinfection with HCV were associated with immune recovery of the HIV patients. CONCLUSIONS: Our study suggests that for HIV-infected Yi patients in Liangshan Prefecture, prompt ART initiation after diagnosis of HIV infection should be applied, and curative HCV treatment should be given to patients with HCV/HIV coinfection to improve the immunological effectiveness of ART. Trial registration None. Twit Text FOAVip Determinants of suboptimal immune recovery among a Chinese Yi ethnicity population with sustained HIV suppression ????BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=35135485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35135485 #FOAvip English Wikipedia <ref>{{Cite pmid|35135485}}</ref> Determinants of suboptimal immune recovery among a Chinese Yi ethnicity population with sustained HIV suppression #MMPMID35135485 Chen L; Liu CH; Kang S; Du L; Ma F; Li C; Bai L; Li H; Tang H BMC Infect Dis 2022[Feb]; 22 (1): 137 PMID35135485show ga OBJECTIVES: Despite sustained viral suppression with effective antiretroviral therapy (ART), HIV-infected patients with suboptimal immune recovery are still at high risk of both non-AIDS-related and AIDS-related events. The aim of this study was to investigate determinants potentially associated with suboptimal CD4 + T cell count recovery during free ART with sustained viral suppression among an HIV-infected Yi ethnicity population in Liangshan Prefecture, an area in China with high HIV prevalence. METHODS: This retrospective study included HIV-infected Yi adults (>/= 18 years and baseline CD4 + T cell count less than 500 cells/muL) for whom ART supported by National Free Antiretroviral Treatment Program was initiated between January 2015 and December 2018 in Zhaojue County, Liangshan Prefecture. Virological suppression (viral load < 50 copies/mL) was achieved within 12 months after ART initiation, and sustained virological suppression was maintained. Multivariate log-binomial regression analysis was used to assess determinants of suboptimal immune recovery. RESULTS: There were 140 female and 137 male patients in this study, with a mean age of 36.57 +/- 7.63 years. Most of the Yi patients were infected through IDU (48.7%) or heterosexual contact (49.8%), and the anti-HCV antibody prevalence was high (43.7%, 121/277). Of the 277 patients with a mean ART duration of 3.77 +/- 1.21 years, complete immune recovery occurred in only 32.9%. The baseline CD4 + T cell count in patients with suboptimal and intermediate immune recovery was 248.64 +/- 108.10 and 288.59 +/- 108.86 cells/muL, respectively, which was much lower than the baseline 320.02 +/- 123.65 cells/muL in patients who achieved complete immune recovery (p < 0.001). Multivariable analysis demonstrated that low pre-ART CD4 + cell count and coinfection with HCV were associated with immune recovery of the HIV patients. CONCLUSIONS: Our study suggests that for HIV-infected Yi patients in Liangshan Prefecture, prompt ART initiation after diagnosis of HIV infection should be applied, and curative HCV treatment should be given to patients with HCV/HIV coinfection to improve the immunological effectiveness of ART. Trial registration None. |*HIV Infections/drug therapy/epidemiology[MESH] |Adult[MESH] |Anti-Retroviral Agents/therapeutic use[MESH] |Antiretroviral Therapy, Highly Active[MESH] |CD4 Lymphocyte Count[MESH] |Ethnicity[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Retrospective Studies[MESH]Determinants of suboptimal immune recovery among a Chinese Yi ethnicit(epmc).pdf DeepDyve Pubget Overpricing