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10.1172/JCI147719 http://scihub22266oqcxt.onion/10.1172/JCI147719 35133977!8970681!35133977     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35133977.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2022 ; 132 (7): ä Nephropedia Template TP {{tp|p=35133977|t=2022. Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes |pdf=|usr=}}{{35133977}} gab.com Text Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=35133977 #FOAvip Trained immunity refers to the long-lasting memory traits of innate immunity. Recent studies have shown that trained immunity is orchestrated by sustained changes in epigenetic marks and metabolic pathways, leading to an altered transcriptional response to a second challenge. However, the potential heterogeneity of trained-immunity induction in innate immune cells has not been explored. In this study, we demonstrate cellular transcriptional programs in response to 4 different inducers of trained immunity in monocyte populations at single-cell resolution. Specifically, we identified 3 monocyte subpopulations upon the induction of trained immunity, and replicated these findings in an in vivo study. In addition, we found gene signatures consistent with these functional programs in patients with ulcerative colitis, sepsis, and COVID-19, suggesting the impact of trained-immunity programs in immune-mediated diseases. Twit Text FOAVip Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=35133977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35133977 #FOAvip English Wikipedia <ref>{{Cite pmid|35133977}}</ref> Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes #MMPMID35133977 Zhang B; Moorlag SJ; Dominguez-Andres J; Bulut O; Kilic G; Liu Z; van Crevel R; Xu CJ; Joosten LA; Netea MG; Li Y J Clin Invest 2022[Apr]; 132 (7): ä PMID35133977show ga Trained immunity refers to the long-lasting memory traits of innate immunity. Recent studies have shown that trained immunity is orchestrated by sustained changes in epigenetic marks and metabolic pathways, leading to an altered transcriptional response to a second challenge. However, the potential heterogeneity of trained-immunity induction in innate immune cells has not been explored. In this study, we demonstrate cellular transcriptional programs in response to 4 different inducers of trained immunity in monocyte populations at single-cell resolution. Specifically, we identified 3 monocyte subpopulations upon the induction of trained immunity, and replicated these findings in an in vivo study. In addition, we found gene signatures consistent with these functional programs in patients with ulcerative colitis, sepsis, and COVID-19, suggesting the impact of trained-immunity programs in immune-mediated diseases. |*COVID-19/genetics[MESH] |*Immune System Diseases[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Immunologic Memory[MESH] |Monocytes[MESH]Single-cell RNA sequencing reveals induction of distinct trained-immun(epmc).pdf DeepDyve Pubget Overpricing