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10.1002/jgm.3415 http://scihub22266oqcxt.onion/10.1002/jgm.3415 35132731!ä!35132731 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gene+Med 2022 ; 24 (5): e3415 Nephropedia Template TP {{tp|p=35132731|t=2022. Histidine-enhanced gene delivery systems: The state of the art |pdf=|usr=}}{{35132731}} gab.com Text Histidine-enhanced gene delivery systems: The state of the art JO: J Gene Med http://www.kidney.de/pget.php?&tw=1&pmid=35132731 #FOAvip Gene therapy has emerged as a promising tool for treating different intractable diseases, particularly cancer or even viral diseases such as COVID-19 (coronavirus disease 2019). In this context, various non-viral gene carriers are being explored to transfer DNA or RNA sequences into target cells. Here, we review the applications of the naturally occurring amino acid histidine in the delivery of nucleic acids into cells. The biocompatibility of histidine-enhanced gene delivery systems has encouraged their wider use in gene therapy. Histidine-based gene carriers can involve the modification of peptides, dendrimers, lipids or nanocomposites. Several linear polymers, such as polyethylenimine, poly-l-lysine (synthetic) or dextran and chitosan (natural), have been conjugated with histidine residues to form complexes with nucleic acids for intracellular delivery. The challenges, opportunities and future research trends of histidine-based gene deliveries are investigated. Twit Text FOAVip Histidine-enhanced gene delivery systems: The state of the art ????J Gene Med http://www.kidney.de/pget.php?&tw=1&pmid=35132731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35132731 #FOAvip English Wikipedia <ref>{{Cite pmid|35132731}}</ref> Histidine-enhanced gene delivery systems: The state of the art #MMPMID35132731 Hooshmand SE; Jahanpeimay Sabet M; Hasanzadeh A; Kamrani Mousavi SM; Haeri Moghaddam N; Hooshmand SA; Rabiee N; Liu Y; Hamblin MR; Karimi M J Gene Med 2022[May]; 24 (5): e3415 PMID35132731show ga Gene therapy has emerged as a promising tool for treating different intractable diseases, particularly cancer or even viral diseases such as COVID-19 (coronavirus disease 2019). In this context, various non-viral gene carriers are being explored to transfer DNA or RNA sequences into target cells. Here, we review the applications of the naturally occurring amino acid histidine in the delivery of nucleic acids into cells. The biocompatibility of histidine-enhanced gene delivery systems has encouraged their wider use in gene therapy. Histidine-based gene carriers can involve the modification of peptides, dendrimers, lipids or nanocomposites. Several linear polymers, such as polyethylenimine, poly-l-lysine (synthetic) or dextran and chitosan (natural), have been conjugated with histidine residues to form complexes with nucleic acids for intracellular delivery. The challenges, opportunities and future research trends of histidine-based gene deliveries are investigated. |*COVID-19/therapy[MESH] |*Nucleic Acids[MESH] |Gene Transfer Techniques[MESH] |Histidine/genetics[MESH] |Humans[MESH]Histidine-enhanced gene delivery systems: The state of the art (epmc).pdf DeepDyve Pubget Overpricing