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10.1101/2022.01.31.478497 http://scihub22266oqcxt.onion/10.1101/2022.01.31.478497 35132419!8820666!35132419     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       bioRxiv 2022 ; ä (ä): ä Nephropedia Template TP {{tp|p=35132419|t=2022. Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries |pdf=|usr=}}{{35132419}} gab.com Text Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=35132419 #FOAvip Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1betais an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1 beta treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1beta treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1beta treated hCOs also provide a viable model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions. Twit Text FOAVip Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=35132419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35132419 #FOAvip English Wikipedia <ref>{{Cite pmid|35132419}}</ref> Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries #MMPMID35132419 Arhontoulis DC; Kerr C; Richards D; Tjen K; Hyams N; Jones JA; Deleon-Pennell K; Menick D; Lindner D; Westermann D; Mei Y bioRxiv 2022[Feb]; ä (ä): ä PMID35132419show ga Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1betais an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammatory cytokines that mirror the profile of COVID-19 cytokine storm. The IL-1 beta treated hCOs recapitulated transcriptomic, structural, and functional signatures of COVID-19 hearts. The comparison of IL-1beta treated hCOs with cardiac tissue from COVID-19 autopsies illustrated the critical roles of hyper-inflammation in COVID-19 cardiac insults and indicated the cardioprotective effects of endothelium. The IL-1beta treated hCOs also provide a viable model to assess the efficacy and potential side effects of immunomodulatory drugs, as well as the reversibility of COVID-19 cardiac injuries at baseline and simulated exercise conditions. äHuman Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardi(epmc).pdf DeepDyve Pubget Overpricing