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10.1016/j.jbc.2022.101677 http://scihub22266oqcxt.onion/10.1016/j.jbc.2022.101677 35131265!8813722!35131265     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2022 ; 298 (3): 101677 Nephropedia Template TP {{tp|p=35131265|t=2022. Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions |pdf=|usr=}}{{35131265}} gab.com Text Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=35131265 #FOAvip In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have reallocated their time and resources to better our understanding of the virus. For some viruses, including SARS-CoV-2, viral proteins can undergo phase separation: a biophysical process often related to the partitioning of protein and RNA into membraneless organelles in vivo. In this review, we discuss emerging observations of phase separation by the SARS-CoV-2 nucleocapsid (N) protein-an essential viral protein required for viral replication-and the possible in vivo functions that have been proposed for N-protein phase separation, including viral replication, viral genomic RNA packaging, and modulation of host-cell response to infection. Additionally, since a relatively large number of studies examining SARS-CoV-2 N-protein phase separation have been published in a short span of time, we take advantage of this situation to compare results from similar experiments across studies. Our evaluation highlights potential strengths and pitfalls of drawing conclusions from a single set of experiments, as well as the value of publishing overlapping scientific observations performed simultaneously by multiple labs. Twit Text FOAVip Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=35131265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35131265 #FOAvip English Wikipedia <ref>{{Cite pmid|35131265}}</ref> Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions #MMPMID35131265 Cascarina SM; Ross ED J Biol Chem 2022[Mar]; 298 (3): 101677 PMID35131265show ga In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have reallocated their time and resources to better our understanding of the virus. For some viruses, including SARS-CoV-2, viral proteins can undergo phase separation: a biophysical process often related to the partitioning of protein and RNA into membraneless organelles in vivo. In this review, we discuss emerging observations of phase separation by the SARS-CoV-2 nucleocapsid (N) protein-an essential viral protein required for viral replication-and the possible in vivo functions that have been proposed for N-protein phase separation, including viral replication, viral genomic RNA packaging, and modulation of host-cell response to infection. Additionally, since a relatively large number of studies examining SARS-CoV-2 N-protein phase separation have been published in a short span of time, we take advantage of this situation to compare results from similar experiments across studies. Our evaluation highlights potential strengths and pitfalls of drawing conclusions from a single set of experiments, as well as the value of publishing overlapping scientific observations performed simultaneously by multiple labs. |*COVID-19/virology[MESH] |*Nucleocapsid Proteins/isolation & purification/metabolism[MESH] |*SARS-CoV-2/chemistry/metabolism[MESH] |Consensus[MESH] |Humans[MESH] |Nucleocapsid/genetics/metabolism[MESH] |RNA, Viral/metabolism[MESH]Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and(epmc).pdf DeepDyve Pubget Overpricing