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10.1002/eji.202149655

http://scihub22266oqcxt.onion/10.1002/eji.202149655
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35128644!9087394!35128644
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suck abstract from ncbi

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  • The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19 #MMPMID35128644
  • Hennings V; Thorn K; Albinsson S; Lingblom C; Andersson K; Andersson C; Jarbur K; Pullerits R; Idorn M; Paludan SR; Eriksson K; Wenneras C
  • Eur J Immunol 2022[May]; 52 (5): 800-809 PMID35128644show ga
  • The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-gamma, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Viral[MESH]
  • |Female[MESH]
  • |Granzymes[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A[MESH]
  • |Immunoglobulin G[MESH]
  • |Male[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Primary Health Care[MESH]


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  • suck abstract from ncbi

    800 5.52 2022