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10.1101/2022.01.23.22269497 http://scihub22266oqcxt.onion/10.1101/2022.01.23.22269497 35118477!8811910!35118477     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       medRxiv 2022 ; ä (ä): ä Nephropedia Template TP {{tp|p=35118477|t=2022. T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components |pdf=|usr=}}{{35118477}} gab.com Text T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components JO: medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=35118477 #FOAvip SARS-CoV-2 provokes a brisk T cell response. Peptide-based studies exclude antigen processing and presentation biology and may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-2 and full-length proteins with DC to activate CD8 and CD4 T cells from convalescent persons. T cell receptor (TCR) sequencing showed partial repertoire preservation after expansion. Resultant CD8 T cells recognize SARS-CoV-2-infected respiratory cells, and CD4 T cells detect inactivated whole viral antigen. Specificity scans with proteome-covering protein/peptide arrays show that CD8 T cells are oligospecific per subject and that CD4 T cell breadth is higher. Some CD4 T cell lines enriched using SARS-CoV-2 cross-recognize whole seasonal coronavirus (sCoV) antigens, with protein, peptide, and HLA restriction validation. Conversely, recognition of some epitopes is eliminated for SARS-CoV-2 variants, including spike (S) epitopes in the alpha, beta, gamma, and delta variant lineages. Twit Text FOAVip T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components ????medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=35118477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35118477 #FOAvip English Wikipedia <ref>{{Cite pmid|35118477}}</ref> T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components #MMPMID35118477 Jing L; Wu X; Krist MP; Hsiang TY; Campbell VL; McClurkan CL; Favors SM; Hemingway LA; Godornes C; Tong DQ; Selke S; LeClair AC; Pyo CW; Geraghty DE; Laing KJ; Wald A; Gale M; Koelle DM medRxiv 2022[Jan]; ä (ä): ä PMID35118477show ga SARS-CoV-2 provokes a brisk T cell response. Peptide-based studies exclude antigen processing and presentation biology and may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-2 and full-length proteins with DC to activate CD8 and CD4 T cells from convalescent persons. T cell receptor (TCR) sequencing showed partial repertoire preservation after expansion. Resultant CD8 T cells recognize SARS-CoV-2-infected respiratory cells, and CD4 T cells detect inactivated whole viral antigen. Specificity scans with proteome-covering protein/peptide arrays show that CD8 T cells are oligospecific per subject and that CD4 T cell breadth is higher. Some CD4 T cell lines enriched using SARS-CoV-2 cross-recognize whole seasonal coronavirus (sCoV) antigens, with protein, peptide, and HLA restriction validation. Conversely, recognition of some epitopes is eliminated for SARS-CoV-2 variants, including spike (S) epitopes in the alpha, beta, gamma, and delta variant lineages. äT cell response to intact SARS-CoV-2 includes coronavirus cross-reacti(epmc).pdf DeepDyve Pubget Overpricing