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10.1038/s41467-022-28315-7 http://scihub22266oqcxt.onion/10.1038/s41467-022-28315-7 35115549!8814034!35115549     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2022 ; 13 (1): 679 Nephropedia Template TP {{tp|p=35115549|t=2022. Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 |pdf=|usr=}}{{35115549}} gab.com Text Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35115549 #FOAvip Emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-related death necessitates better understanding of the early viral dynamics, host responses and immunopathology. Single cell RNAseq (scRNAseq) allows for the study of individual cells, uncovering heterogeneous and variable responses to environment, infection and inflammation. While studies have reported immune profiling using scRNAseq in terminal human COVID-19 patients, performing longitudinal immune cell dynamics in humans is challenging. Macaques are a suitable model of SARS-CoV-2 infection. Our longitudinal scRNAseq of bronchoalveolar lavage (BAL) cell suspensions from young rhesus macaques infected with SARS-CoV-2 (n = 6) demonstrates dynamic changes in transcriptional landscape 3 days post- SARS-CoV-2-infection (3dpi; peak viremia), relative to 14-17dpi (recovery phase) and pre-infection (baseline) showing accumulation of distinct populations of both macrophages and T-lymphocytes expressing strong interferon-driven inflammatory gene signature at 3dpi. Type I interferon response is induced in the plasmacytoid dendritic cells with appearance of a distinct HLADR(+)CD68(+)CD163(+)SIGLEC1(+) macrophage population exhibiting higher angiotensin-converting enzyme 2 (ACE2) expression. These macrophages are significantly enriched in the lungs of macaques at 3dpi and harbor SARS-CoV-2 while expressing a strong interferon-driven innate anti-viral gene signature. The accumulation of these responses correlated with decline in viremia and recovery. Twit Text FOAVip Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35115549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35115549 #FOAvip English Wikipedia <ref>{{Cite pmid|35115549}}</ref> Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 #MMPMID35115549 Singh DK; Aladyeva E; Das S; Singh B; Esaulova E; Swain A; Ahmed M; Cole J; Moodley C; Mehra S; Schlesinger LS; Artyomov MN; Khader SA; Kaushal D Nat Commun 2022[Feb]; 13 (1): 679 PMID35115549show ga Emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-related death necessitates better understanding of the early viral dynamics, host responses and immunopathology. Single cell RNAseq (scRNAseq) allows for the study of individual cells, uncovering heterogeneous and variable responses to environment, infection and inflammation. While studies have reported immune profiling using scRNAseq in terminal human COVID-19 patients, performing longitudinal immune cell dynamics in humans is challenging. Macaques are a suitable model of SARS-CoV-2 infection. Our longitudinal scRNAseq of bronchoalveolar lavage (BAL) cell suspensions from young rhesus macaques infected with SARS-CoV-2 (n = 6) demonstrates dynamic changes in transcriptional landscape 3 days post- SARS-CoV-2-infection (3dpi; peak viremia), relative to 14-17dpi (recovery phase) and pre-infection (baseline) showing accumulation of distinct populations of both macrophages and T-lymphocytes expressing strong interferon-driven inflammatory gene signature at 3dpi. Type I interferon response is induced in the plasmacytoid dendritic cells with appearance of a distinct HLADR(+)CD68(+)CD163(+)SIGLEC1(+) macrophage population exhibiting higher angiotensin-converting enzyme 2 (ACE2) expression. These macrophages are significantly enriched in the lungs of macaques at 3dpi and harbor SARS-CoV-2 while expressing a strong interferon-driven innate anti-viral gene signature. The accumulation of these responses correlated with decline in viremia and recovery. |Animals[MESH] |Antiviral Agents[MESH] |Bronchoalveolar Lavage[MESH] |COVID-19/*immunology[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation[MESH] |Interferon Type I/genetics/pharmacology[MESH] |Interferons/genetics/*pharmacology[MESH] |Lung/immunology/pathology[MESH] |Macaca mulatta[MESH] |Macrophages/immunology[MESH] |Myeloid Cells/*immunology[MESH] |SARS-CoV-2/*drug effects[MESH]Myeloid cell interferon responses correlate with clearance of SARS-CoV(epmc).pdf DeepDyve Pubget Overpricing