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10.3389/fimmu.2021.785941 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.785941 35111156!8801440!35111156     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35111156&cmd=llinks): Failed to open stream: HTTP request failed! 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Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response |pdf=|usr=}}{{35111156}} gab.com Text Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35111156 #FOAvip Coronavirus disease 2019 (COVID-19) is an infectious disease caused by beta-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has rapidly spread across the globe starting from February 2020. It is well established that during viral infection, extracellular vesicles become delivery/presenting vectors of viral material. However, studies regarding extracellular vesicle function in COVID-19 pathology are still scanty. Here, we performed a comparative study on exosomes recovered from the plasma of either MILD or SEVERE COVID-19 patients. We show that although both types of vesicles efficiently display SARS-CoV-2 spike-derived peptides and carry immunomodulatory molecules, only those of MILD patients are capable of efficiently regulating antigen-specific CD4(+) T-cell responses. Accordingly, by mass spectrometry, we show that the proteome of exosomes of MILD patients correlates with a proper functioning of the immune system, while that of SEVERE patients is associated with increased and chronic inflammation. Overall, we show that exosomes recovered from the plasma of COVID-19 patients possess SARS-CoV-2-derived protein material, have an active role in enhancing the immune response, and possess a cargo that reflects the pathological state of patients in the acute phase of the disease. Twit Text FOAVip Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35111156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35111156 #FOAvip English Wikipedia <ref>{{Cite pmid|35111156}}</ref> Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response #MMPMID35111156 Pesce E; Manfrini N; Cordiglieri C; Santi S; Bandera A; Gobbini A; Gruarin P; Favalli A; Bombaci M; Cuomo A; Collino F; Cricri G; Ungaro R; Lombardi A; Mangioni D; Muscatello A; Aliberti S; Blasi F; Gori A; Abrignani S; De Francesco R; Biffo S; Grifantini R Front Immunol 2021[]; 12 (ä): 785941 PMID35111156show ga Coronavirus disease 2019 (COVID-19) is an infectious disease caused by beta-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has rapidly spread across the globe starting from February 2020. It is well established that during viral infection, extracellular vesicles become delivery/presenting vectors of viral material. However, studies regarding extracellular vesicle function in COVID-19 pathology are still scanty. Here, we performed a comparative study on exosomes recovered from the plasma of either MILD or SEVERE COVID-19 patients. We show that although both types of vesicles efficiently display SARS-CoV-2 spike-derived peptides and carry immunomodulatory molecules, only those of MILD patients are capable of efficiently regulating antigen-specific CD4(+) T-cell responses. Accordingly, by mass spectrometry, we show that the proteome of exosomes of MILD patients correlates with a proper functioning of the immune system, while that of SEVERE patients is associated with increased and chronic inflammation. Overall, we show that exosomes recovered from the plasma of COVID-19 patients possess SARS-CoV-2-derived protein material, have an active role in enhancing the immune response, and possess a cargo that reflects the pathological state of patients in the acute phase of the disease. |*Adaptive Immunity[MESH] |Acute Disease[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/blood/*immunology[MESH] |Exosomes/*immunology/metabolism[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Plasma[MESH] |SARS-CoV-2/*immunology/metabolism[MESH]Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-Co(epmc).pdf DeepDyve Pubget Overpricing