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10.26508/lsa.202201371

http://scihub22266oqcxt.onion/10.26508/lsa.202201371
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35110370!8814637!35110370
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suck abstract from ncbi


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pmid35110370      Life+Sci+Alliance 2022 ; 5 (5): ä
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  • Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells #MMPMID35110370
  • Kohli A; Sauerhering L; Fehling SK; Klann K; Geiger H; Becker S; Koch B; Baer PC; Strecker T; Munch C
  • Life Sci Alliance 2022[May]; 5 (5): ä PMID35110370show ga
  • Acute kidney injury is associated with mortality in COVID-19 patients. However, host cell changes underlying infection of renal cells with SARS-CoV-2 remain unknown and prevent understanding of the molecular mechanisms that may contribute to renal pathology. Here, we carried out quantitative translatome and whole-cell proteomics analyses of primary renal proximal and distal tubular epithelial cells derived from human donors infected with SARS-CoV-2 or MERS-CoV to disseminate virus and cell type-specific changes over time. Our findings revealed shared pathways modified upon infection with both viruses, as well as SARS-CoV-2-specific host cell modulation driving key changes in innate immune activation and cellular protein quality control. Notably, MERS-CoV infection-induced specific changes in mitochondrial biology that were not observed in response to SARS-CoV-2 infection. Furthermore, we identified extensive modulation in pathways associated with kidney failure that changed in a virus- and cell type-specific manner. In summary, we provide an overview of the effects of SARS-CoV-2 or MERS-CoV infection on primary renal epithelial cells revealing key pathways that may be essential for viral replication.
  • |*Kidney[MESH]
  • |*Proteome[MESH]
  • |*Proteomics/methods[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/metabolism/virology[MESH]
  • |Cell Nucleus/genetics/metabolism[MESH]
  • |Cells, Cultured[MESH]
  • |Computational Biology/methods[MESH]
  • |Coronavirus Infections/metabolism/virology[MESH]
  • |Epithelial Cells/*metabolism/*virology[MESH]
  • |Gene Expression Regulation[MESH]
  • |Host-Pathogen Interactions/genetics/immunology[MESH]
  • |Humans[MESH]
  • |Kidney Tubules, Distal[MESH]
  • |Kidney Tubules, Proximal[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/*physiology[MESH]
  • |Mitochondria/genetics/metabolism[MESH]
  • |Primary Cell Culture[MESH]
  • |SARS-CoV-2/*physiology[MESH]


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