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10.26508/lsa.202201371 http://scihub22266oqcxt.onion/10.26508/lsa.202201371 35110370!8814637!35110370     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35110370.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Life+Sci+Alliance 2022 ; 5 (5): ä Nephropedia Template TP {{tp|p=35110370|t=2022. Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells |pdf=|usr=}}{{35110370}} gab.com Text Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells JO: Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=35110370 #FOAvip Acute kidney injury is associated with mortality in COVID-19 patients. However, host cell changes underlying infection of renal cells with SARS-CoV-2 remain unknown and prevent understanding of the molecular mechanisms that may contribute to renal pathology. Here, we carried out quantitative translatome and whole-cell proteomics analyses of primary renal proximal and distal tubular epithelial cells derived from human donors infected with SARS-CoV-2 or MERS-CoV to disseminate virus and cell type-specific changes over time. Our findings revealed shared pathways modified upon infection with both viruses, as well as SARS-CoV-2-specific host cell modulation driving key changes in innate immune activation and cellular protein quality control. Notably, MERS-CoV infection-induced specific changes in mitochondrial biology that were not observed in response to SARS-CoV-2 infection. Furthermore, we identified extensive modulation in pathways associated with kidney failure that changed in a virus- and cell type-specific manner. In summary, we provide an overview of the effects of SARS-CoV-2 or MERS-CoV infection on primary renal epithelial cells revealing key pathways that may be essential for viral replication. Twit Text FOAVip Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells ????Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=35110370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35110370 #FOAvip English Wikipedia <ref>{{Cite pmid|35110370}}</ref> Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells #MMPMID35110370 Kohli A; Sauerhering L; Fehling SK; Klann K; Geiger H; Becker S; Koch B; Baer PC; Strecker T; Munch C Life Sci Alliance 2022[May]; 5 (5): ä PMID35110370show ga Acute kidney injury is associated with mortality in COVID-19 patients. However, host cell changes underlying infection of renal cells with SARS-CoV-2 remain unknown and prevent understanding of the molecular mechanisms that may contribute to renal pathology. Here, we carried out quantitative translatome and whole-cell proteomics analyses of primary renal proximal and distal tubular epithelial cells derived from human donors infected with SARS-CoV-2 or MERS-CoV to disseminate virus and cell type-specific changes over time. Our findings revealed shared pathways modified upon infection with both viruses, as well as SARS-CoV-2-specific host cell modulation driving key changes in innate immune activation and cellular protein quality control. Notably, MERS-CoV infection-induced specific changes in mitochondrial biology that were not observed in response to SARS-CoV-2 infection. Furthermore, we identified extensive modulation in pathways associated with kidney failure that changed in a virus- and cell type-specific manner. In summary, we provide an overview of the effects of SARS-CoV-2 or MERS-CoV infection on primary renal epithelial cells revealing key pathways that may be essential for viral replication. |*Kidney[MESH] |*Proteome[MESH] |*Proteomics/methods[MESH] |Biomarkers[MESH] |COVID-19/metabolism/virology[MESH] |Cell Nucleus/genetics/metabolism[MESH] |Cells, Cultured[MESH] |Computational Biology/methods[MESH] |Coronavirus Infections/metabolism/virology[MESH] |Epithelial Cells/*metabolism/*virology[MESH] |Gene Expression Regulation[MESH] |Host-Pathogen Interactions/genetics/immunology[MESH] |Humans[MESH] |Kidney Tubules, Distal[MESH] |Kidney Tubules, Proximal[MESH] |Middle East Respiratory Syndrome Coronavirus/*physiology[MESH] |Mitochondria/genetics/metabolism[MESH] |Primary Cell Culture[MESH] |SARS-CoV-2/*physiology[MESH]Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human(epmc).pdf DeepDyve Pubget Overpricing