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10.1186/s40478-022-01313-y

http://scihub22266oqcxt.onion/10.1186/s40478-022-01313-y
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35105380!8805426!35105380
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suck abstract from ncbi


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pmid35105380      Acta+Neuropathol+Commun 2022 ; 10 (1): 14
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  • Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients #MMPMID35105380
  • Genchi A; Semerano A; Schwarz G; Dell'Acqua B; Gullotta GS; Sampaolo M; Boeri E; Quattrini A; Sanvito F; Diamanti S; Bergamaschi A; Grassi S; Podini P; Panni P; Michelozzi C; Simionato F; Scomazzoni F; Remida P; Valvassori L; Falini A; Ferrarese C; Michel P; Saliou G; Hajdu S; Beretta S; Roveri L; Filippi M; Strambo D; Martino G; Bacigaluppi M
  • Acta Neuropathol Commun 2022[Feb]; 10 (1): 14 PMID35105380show ga
  • Coronavirus disease 2019 (COVID-19) is associated with an increased risk of thrombotic events. Ischemic stroke in COVID-19 patients entails high severity and mortality rates. Here we aimed to analyze cerebral thrombi of COVID-19 patients with large vessel occlusion (LVO) acute ischemic stroke to expose molecular evidence for SARS-CoV-2 in the thrombus and to unravel any peculiar immune-thrombotic features. We conducted a systematic pathological analysis of cerebral thrombi retrieved by endovascular thrombectomy in patients with LVO stroke infected with COVID-19 (n = 7 patients) and non-covid LVO controls (n = 23). In thrombi of COVID-19 patients, the SARS-CoV-2 docking receptor ACE2 was mainly expressed in monocytes/macrophages and showed higher expression levels compared to controls. Using polymerase chain reaction and sequencing, we detected SARS-CoV-2 Clade20A, in the thrombus of one COVID-19 patient. Comparing thrombus composition of COVID-19 and control patients, we noted no overt differences in terms of red blood cells, fibrin, neutrophil extracellular traps (NETs), von Willebrand Factor (vWF), platelets and complement complex C5b-9. However, thrombi of COVID-19 patients showed increased neutrophil density (MPO(+) cells) and a three-fold higher Neutrophil-to-Lymphocyte Ratio (tNLR). In the ROC analysis both neutrophils and tNLR had a good discriminative ability to differentiate thrombi of COVID-19 patients from controls. In summary, cerebral thrombi of COVID-19 patients can harbor SARS-CoV2 and are characterized by an increased neutrophil number and tNLR and higher ACE2 expression. These findings suggest neutrophils as the possible culprit in COVID-19-related thrombosis.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Angiotensin-Converting Enzyme 2/blood/genetics/immunology[MESH]
  • |Brain Ischemia/blood/genetics/*immunology[MESH]
  • |COVID-19/blood/genetics/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunity, Cellular/*physiology[MESH]
  • |Intracranial Thrombosis/blood/genetics/*immunology[MESH]
  • |Male[MESH]
  • |Mechanical Thrombolysis/methods[MESH]
  • |Middle Aged[MESH]
  • |Neutrophils/*immunology/metabolism[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2/genetics/immunology/metabolism[MESH]


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