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10.3389/fimmu.2021.809937 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.809937 35095900!8790058!35095900     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 809937 Nephropedia Template TP {{tp|p=35095900|t=2021. Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment |pdf=|usr=}}{{35095900}} gab.com Text Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35095900 #FOAvip Deep understanding of the SARS-CoV-2 effects on host molecular pathways is paramount for the discovery of early biomarkers of outcome of coronavirus disease 2019 (COVID-19) and the identification of novel therapeutic targets. In that light, we generated metabolomic data from COVID-19 patient blood using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy and high-dimensional flow cytometry. We find considerable changes in serum metabolome composition of COVID-19 patients associated with disease severity, and response to tocilizumab treatment. We built a clinically annotated, biologically-interpretable space for precise time-resolved disease monitoring and characterize the temporal dynamics of metabolomic change along the clinical course of COVID-19 patients and in response to therapy. Finally, we leverage joint immuno-metabolic measurements to provide a novel approach for patient stratification and early prediction of severe disease. Our results show that high-dimensional metabolomic and joint immune-metabolic readouts provide rich information content for elucidation of the host's response to infection and empower discovery of novel metabolic-driven therapies, as well as precise and efficient clinical action. Twit Text FOAVip Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35095900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35095900 #FOAvip English Wikipedia <ref>{{Cite pmid|35095900}}</ref> Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment #MMPMID35095900 Rendeiro AF; Vorkas CK; Krumsiek J; Singh HK; Kapadia SN; Cappelli LV; Cacciapuoti MT; Inghirami G; Elemento O; Salvatore M Front Immunol 2021[]; 12 (ä): 809937 PMID35095900show ga Deep understanding of the SARS-CoV-2 effects on host molecular pathways is paramount for the discovery of early biomarkers of outcome of coronavirus disease 2019 (COVID-19) and the identification of novel therapeutic targets. In that light, we generated metabolomic data from COVID-19 patient blood using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy and high-dimensional flow cytometry. We find considerable changes in serum metabolome composition of COVID-19 patients associated with disease severity, and response to tocilizumab treatment. We built a clinically annotated, biologically-interpretable space for precise time-resolved disease monitoring and characterize the temporal dynamics of metabolomic change along the clinical course of COVID-19 patients and in response to therapy. Finally, we leverage joint immuno-metabolic measurements to provide a novel approach for patient stratification and early prediction of severe disease. Our results show that high-dimensional metabolomic and joint immune-metabolic readouts provide rich information content for elucidation of the host's response to infection and empower discovery of novel metabolic-driven therapies, as well as precise and efficient clinical action. |Adult[MESH] |Aged[MESH] |Biochemical Phenomena/immunology[MESH] |Biomarkers/blood/*metabolism[MESH] |COVID-19/blood/*immunology/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Metabolome/*immunology[MESH] |Metabolomics/methods[MESH] |Middle Aged[MESH]Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severi(epmc).pdf DeepDyve Pubget Overpricing