Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.3389/fimmu.2021.782335

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.782335
suck pdf from google scholar
35095856!8790015!35095856
unlimited free pdf from europmc35095856    free
PDF from PMC    free
html from PMC    free
PDF vom PMID35095856 :   free

suck abstract from ncbi

pmid35095856
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Potential Anionic Substances Binding to Platelet Factor 4 in Vaccine-Induced Thrombotic Thrombocytopenia of ChAdOx1-S Vaccine for SARS-CoV-2 #MMPMID35095856
  • Pang X; Liu H; He X; Ji T; Zhu Y; Cui Y
  • Front Immunol 2021[]; 12 (ä): 782335 PMID35095856show ga
  • Recent reports of rare ChAdOx1-S vaccine-related venous thrombosis led to the suspension of its usage in several countries. Vaccine-induced thrombotic thrombocytopenia (VITT) is characterized by thrombocytopenia and thrombosis in association with anti-platelet factor 4 (PF4) antibodies. Herein, we propose five potential anionic substances of the ChAdOx1-S vaccine that can combine with PF4 and trigger VITT, including (1) the proteins on the surface of adenovirus, e.g., negative charged glycoprotein, (2) the adjuvant components of the vaccine, e.g., Tween 80, (3) the DNA of adenovirus, (4) the S protein antigen expressed by the vaccine, and (5) the negatively charged impurity proteins expressed by the vaccine, e.g., adenovirus skeleton proteins. After analysis of each case, we consider the most possible trigger to be the negatively charged impurity proteins expressed by the vaccine. Then, we display the possible extravascular route and intravascular route of the formation of PF4 autoantibodies triggered by the negatively charged impurity proteins, which is accordant with the clinical situation. Accordingly, the susceptible individuals of VITT after ChAdOx1-S vaccination may be people who express negatively charged impurity proteins and reach a certain high titer.
  • |Adenovirus Vaccines/adverse effects/immunology[MESH]
  • |Adjuvants, Immunologic/administration & dosage[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19/immunology[MESH]
  • |ChAdOx1 nCoV-19/*adverse effects/*immunology[MESH]
  • |Humans[MESH]
  • |Platelet Factor 4/*immunology[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology[MESH]
  • |Thrombocytopenia/*chemically induced[MESH]
  • |Thrombosis/*chemically induced[MESH]
  • |Vaccination/*adverse effects[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    782335 ä.12 2021