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10.1016/j.micpath.2022.105416 http://scihub22266oqcxt.onion/10.1016/j.micpath.2022.105416 35092836!8789556!35092836     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microb+Pathog 2022 ; 164 (ä): 105416 Nephropedia Template TP {{tp|p=35092836|t=2022. The effect of IGF-1 plasma concentration on COVID-19 severity |pdf=|usr=}}{{35092836}} gab.com Text The effect of IGF-1 plasma concentration on COVID-19 severity JO: Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=35092836 #FOAvip BACKGROUND: The severity and fatality of Coronavirus disease 2019 (COVID-19) infection are not the same in the infected population. The host immune response and Immune-stimulating factors appear to play a role in COVID-19 infection outcome. insulin-like growth factor-1 (IGF-1) affects the immune system by controlling the endocrine system. Recently, the effect of IGF-1 levels on COVID-19 prognosis has been considered. OBJECTIVE: To investigate the difference between circulating IGF-1 and inflammatory cytokines concentration among COVID-19 patients, infected patients admitted to the Intensive Care Unit (ICU) (n = 40; 35 +/- 5 y) and patients with mild cases of COVID-19 (n = 40; 35 +/- 5 y) were screened prior to participation in the study. There was no significant difference between the groups in terms of gender and preexisting inflammatory state. Collected samples were evaluated by ELISA for IGF-1 and IL-6. RESULTS: The study outcomes included a significant decrease in IGF-1 and an increase in IL-6 serum concentration, as an inflammatory marker, for infected patients admitted to the Intensive Care Unit (ICU) (P </= 0.001). Finally, there was a significant increase in the IGF-1 and a decrease in the IL-6 serum concentration of hospitalized patients. DISCUSSION: it appears that inflammatory cytokines (IL-6) serum concentration in the severe form of corona virus-based infections causes reduced defenses because of suppressed IGF-1. CONCLUSIONS: Our findings show that lower IGF-1 concentrations are associated with a Severe form of COVID-19 disease. It seems, IGF-1 supplementation or anti-inflammatory treatment rescued the severe form of COVID-19 infection. Further studies are required to determine how to design COVID-19 therapeutic strategies targeting the IGF-1 pathway. Twit Text FOAVip The effect of IGF-1 plasma concentration on COVID-19 severity ????Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=35092836 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35092836 #FOAvip English Wikipedia <ref>{{Cite pmid|35092836}}</ref> The effect of IGF-1 plasma concentration on COVID-19 severity #MMPMID35092836 Hazrati E; Gholami M; Farahani RH; Ghorban K; Ghayomzadeh M; Rouzbahani NH Microb Pathog 2022[Mar]; 164 (ä): 105416 PMID35092836show ga BACKGROUND: The severity and fatality of Coronavirus disease 2019 (COVID-19) infection are not the same in the infected population. The host immune response and Immune-stimulating factors appear to play a role in COVID-19 infection outcome. insulin-like growth factor-1 (IGF-1) affects the immune system by controlling the endocrine system. Recently, the effect of IGF-1 levels on COVID-19 prognosis has been considered. OBJECTIVE: To investigate the difference between circulating IGF-1 and inflammatory cytokines concentration among COVID-19 patients, infected patients admitted to the Intensive Care Unit (ICU) (n = 40; 35 +/- 5 y) and patients with mild cases of COVID-19 (n = 40; 35 +/- 5 y) were screened prior to participation in the study. There was no significant difference between the groups in terms of gender and preexisting inflammatory state. Collected samples were evaluated by ELISA for IGF-1 and IL-6. RESULTS: The study outcomes included a significant decrease in IGF-1 and an increase in IL-6 serum concentration, as an inflammatory marker, for infected patients admitted to the Intensive Care Unit (ICU) (P |*COVID-19[MESH] |Humans[MESH] |Insulin-Like Growth Factor I[MESH] |Intensive Care Units[MESH] |Prognosis[MESH]The effect of IGF-1 plasma concentration on COVID-19 severity (epmc).pdf DeepDyve Pubget Overpricing