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10.3389/fmolb.2021.772788

http://scihub22266oqcxt.onion/10.3389/fmolb.2021.772788
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suck abstract from ncbi


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pmid35087864      Front+Mol+Biosci 2021 ; 8 (ä): 772788
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  • CRISPR Technology in Gene-Editing-Based Detection and Treatment of SARS-CoV-2 #MMPMID35087864
  • Shademan B; Nourazarian A; Hajazimian S; Isazadeh A; Biray Avci C; Oskouee MA
  • Front Mol Biosci 2021[]; 8 (ä): 772788 PMID35087864show ga
  • Outbreak and rapid spread of coronavirus disease (COVID-19) caused by coronavirus acute respiratory syndrome (SARS-CoV-2) caused severe acute respiratory syndrome (SARS-CoV-2) that started in Wuhan, and has become a global problem because of the high rate of human-to-human transmission and severe respiratory infections. Because of high prevalence of SARS-CoV-2, which threatens many people worldwide, rapid diagnosis and simple treatment are needed. Genome editing is a nucleic acid-based approach to altering the genome by artificially changes in genetic information and induce irreversible changes in the function of target gene. Clustered, regularly interspaced short palindromic repeats (CRISPR/Cas) could be a practical and straightforward approach to this disease. CRISPR/Cas system contains Cas protein, which is controlled by a small RNA molecule to create a double-stranded DNA gap. Evidence suggested that CRISPR/Cas was also usable for diagnosis and treatment of SARS-CoV-2 infection. In this review study, we discoursed on application of CRISPR technology in detection and treatment of SARS-CoV-2 infection. Another aspect of this study was to introduce potential future problems in use of CRISPR/Cas technology.
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