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10.1016/j.trsl.2022.01.004

http://scihub22266oqcxt.onion/10.1016/j.trsl.2022.01.004
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35085821!8785258!35085821
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suck abstract from ncbi


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pmid35085821      Transl+Res 2022 ; 243 (ä): 14-20
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  • Post-COVID-19 patients show an increased endothelial progenitor cell production #MMPMID35085821
  • Poyatos P; Luque N; Eizaguirre S; Sabater G; Sebastian L; Francisco-Albesa I; Peracaula M; Boixade M; Orriols R; Tura-Ceide O
  • Transl Res 2022[May]; 243 (ä): 14-20 PMID35085821show ga
  • SARS-CoV-2, the cause of COVID-19, has generated a global emergency. The endothelium is a target of SARS-CoV-2, generating endothelial dysfunction, an essential step for the development of cardiovascular complications. The number of endothelial progenitor cells acts as an indicator of vascular damage. However, its role in SARS-CoV-2 is unknown. The aim of this study was to quantify the number of endothelial colony forming cells (ECFCs) and assess for the first time if there is a significant increase after SARS-CoV-2 infection. This study also evaluates whether the number of ECFC is related to the presence of pulmonary embolism (PE), and if this increase correlates with any of the clinical parameters studied. A total of 63 subjects were recruited including 32 subjects 3-months after overcoming COVID-19 and 31 healthy controls. The results confirm the presence of vascular sequelae in post-COVID-19 patients, with an abnormal increase in the number of ECFCs in blood circulation compared to controls (2.81 +/- 2.33 vs 1.23 +/- 1.86, P = 0.001). There was no difference in ECFC production in COVID-19 who presented acute PE compared to those that did not (3.21 +/- 2.49 vs 2.50 +/- 2.23, P > 0.05). The appearance of ECFC colonies in COVID-19 patients was significantly related to male gender (P = 0.003), the presence of systemic hypertension (P = 0.01) and elevated hemoglobin levels (P = 0.02) at the time of ECFC isolation and lower PaO(2) levels (P = 0.01) at admission. Whether these results indicate a prompt response of the patient to repair the damaged endothelium or reflect a postinfection injury that will persist in time is not known.
  • |*COVID-19[MESH]
  • |*Endothelial Progenitor Cells[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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