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10.1016/j.abb.2022.109124 http://scihub22266oqcxt.onion/10.1016/j.abb.2022.109124 35085577!8785432!35085577     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35085577.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arch+Biochem+Biophys 2022 ; 717 (ä): 109124 Nephropedia Template TP {{tp|p=35085577|t=2022. The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 |pdf=|usr=}}{{35085577}} gab.com Text The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 JO: Arch Biochem Biophys http://www.kidney.de/pget.php?&tw=1&pmid=35085577 #FOAvip The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1beta (IL-1beta) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2. Twit Text FOAVip The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 ????Arch Biochem Biophys http://www.kidney.de/pget.php?&tw=1&pmid=35085577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35085577 #FOAvip English Wikipedia <ref>{{Cite pmid|35085577}}</ref> The importance of accessory protein variants in the pathogenicity of SARS-CoV-2 #MMPMID35085577 Hassan SS; Choudhury PP; Dayhoff GW 2nd; Aljabali AAA; Uhal BD; Lundstrom K; Rezaei N; Pizzol D; Adadi P; Lal A; Soares A; Mohamed Abd El-Aziz T; Brufsky AM; Azad GK; Sherchan SP; Baetas-da-Cruz W; Takayama K; Serrano-Aroca A; Chauhan G; Palu G; Mishra YK; Barh D; Santana Silva RJ; Andrade BS; Azevedo V; Goes-Neto A; Bazan NG; Redwan EM; Tambuwala M; Uversky VN Arch Biochem Biophys 2022[Mar]; 717 (ä): 109124 PMID35085577show ga The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1beta (IL-1beta) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2. |COVID-19/pathology/*virology[MESH] |Genetic Variation[MESH] |Humans[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Viral Proteins/*genetics[MESH]The importance of accessory protein variants in the pathogenicity of S(epmc).pdf DeepDyve Pubget Overpricing