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10.1371/journal.pone.0262751 http://scihub22266oqcxt.onion/10.1371/journal.pone.0262751 35085325!8794112!35085325     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2022 ; 17 (1): e0262751 Nephropedia Template TP {{tp|p=35085325|t=2022. Identification of potentially anti-COVID-19 active drugs using the connectivity MAP |pdf=|usr=}}{{35085325}} gab.com Text Identification of potentially anti-COVID-19 active drugs using the connectivity MAP JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=35085325 #FOAvip Drug repurposing can be an interesting strategy for an emergency response to the severe acute respiratory syndrome-coronavirus-2, (SARS-COV-2), the causing agent of the coronavirus disease-19 (COVID-19) pandemic. For this, we applied the Connectivity Map (CMap) bioinformatic resource to identify drugs that generate, in the CMap database, gene expression profiles (GEP) that negatively correlate with a SARS-COV-2 GEP, anticipating that these drugs could antagonize the deleterious effects of the virus at cell, tissue or organism levels. We identified several anti-cancer compounds that target MDM2 in the p53 pathway or signaling proteins: Ras, PKBbeta, Nitric Oxide synthase, Rho kinase, all involved in the transmission of proliferative and growth signals. We hypothesized that these drugs could interfere with the high rate of biomass synthesis in infected cells, a feature shared with cancer cells. Other compounds including etomoxir, triacsin-c, PTB1-IN-3, are known to modulate lipid metabolism or to favor catabolic reactions by activating AMPK. Four different anti-inflammatory molecules, including dexamethasone, fluorometholone and cytosporone-b, targeting the glucocorticoid receptor, cyclooxygenase, or NUR77 also came out of the analysis. These results represent a first step in the characterization of potential repositioning strategies to treat SARS-COV-2. Twit Text FOAVip Identification of potentially anti-COVID-19 active drugs using the connectivity MAP ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=35085325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35085325 #FOAvip English Wikipedia <ref>{{Cite pmid|35085325}}</ref> Identification of potentially anti-COVID-19 active drugs using the connectivity MAP #MMPMID35085325 Bonnet R; Mariault L; Peyron JF PLoS One 2022[]; 17 (1): e0262751 PMID35085325show ga Drug repurposing can be an interesting strategy for an emergency response to the severe acute respiratory syndrome-coronavirus-2, (SARS-COV-2), the causing agent of the coronavirus disease-19 (COVID-19) pandemic. For this, we applied the Connectivity Map (CMap) bioinformatic resource to identify drugs that generate, in the CMap database, gene expression profiles (GEP) that negatively correlate with a SARS-COV-2 GEP, anticipating that these drugs could antagonize the deleterious effects of the virus at cell, tissue or organism levels. We identified several anti-cancer compounds that target MDM2 in the p53 pathway or signaling proteins: Ras, PKBbeta, Nitric Oxide synthase, Rho kinase, all involved in the transmission of proliferative and growth signals. We hypothesized that these drugs could interfere with the high rate of biomass synthesis in infected cells, a feature shared with cancer cells. Other compounds including etomoxir, triacsin-c, PTB1-IN-3, are known to modulate lipid metabolism or to favor catabolic reactions by activating AMPK. Four different anti-inflammatory molecules, including dexamethasone, fluorometholone and cytosporone-b, targeting the glucocorticoid receptor, cyclooxygenase, or NUR77 also came out of the analysis. These results represent a first step in the characterization of potential repositioning strategies to treat SARS-COV-2. |*COVID-19 Drug Treatment[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Antineoplastic Agents/therapeutic use[MESH] |Antiviral Agents/therapeutic use[MESH] |Computational Biology/methods[MESH] |Databases, Genetic[MESH] |Drug Repositioning/*methods[MESH] |Gene Expression/drug effects[MESH] |Humans[MESH] |Models, Theoretical[MESH] |Pandemics[MESH] |Pharmaceutical Preparations[MESH] |SARS-CoV-2/*drug effects/pathogenicity[MESH]Identification of potentially anti-COVID-19 active drugs using the con(epmc).pdf DeepDyve Pubget Overpricing