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10.1021/acs.biomac.1c01447 http://scihub22266oqcxt.onion/10.1021/acs.biomac.1c01447 35080884!ä!35080884 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomacromolecules 2022 ; 23 (3): 1158-1168 Nephropedia Template TP {{tp|p=35080884|t=2022. Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation |pdf=|usr=}}{{35080884}} gab.com Text Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation JO: Biomacromolecules http://www.kidney.de/pget.php?&tw=1&pmid=35080884 #FOAvip Coronavirus disease 2019 (Covid-19) has caused over 5.5 million deaths worldwide, and viral mutants continue to ravage communities with limited access to injectable vaccines or high rates of vaccine hesitancy. Inhalable vaccines have the potential to address these distribution and compliance issues as they are less likely to require cold storage, avoid the use of needles, and can elicit localized immune responses with only a single dose. Alveolar macrophages represent attractive targets for inhalable vaccines as they are abundant within the lung mucosa (up to 95% of all immune cells) and are important mediators of mucosal immunity, and evidence suggests that they may be key cellular players in early Covid-19 pathogenesis. Here, we report inhalable coronavirus mimetic particles (CoMiP) designed to rapidly bind to, and be internalized by, alveolar macrophages to deliver nucleic acid-encoded viral antigens. Inspired by the SARS-CoV-2 virion structure, CoMiP carriers package nucleic acid cargo within an endosomolytic peptide envelope that is wrapped in a macrophage-targeting glycosaminoglycan coating. Through this design, CoMiP mimic several important features of the SARS-CoV-2 virion, particularly surface topography and macromolecular chemistry. As a result, CoMiP effect pleiotropic transfection of macrophages and lung epithelial cells in vitro with multiple antigen-encoding plasmids. In vivo immunization yields increased mucosal IgA levels within the respiratory tract of CoMiP vaccinated mice. Twit Text FOAVip Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation ????Biomacromolecules http://www.kidney.de/pget.php?&tw=1&pmid=35080884 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35080884 #FOAvip English Wikipedia <ref>{{Cite pmid|35080884}}</ref> Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation #MMPMID35080884 Lawanprasert A; Simonson AW; Sumner SE; Nicol MJ; Pimcharoen S; Kirimanjeswara GS; Medina SH Biomacromolecules 2022[Mar]; 23 (3): 1158-1168 PMID35080884show ga Coronavirus disease 2019 (Covid-19) has caused over 5.5 million deaths worldwide, and viral mutants continue to ravage communities with limited access to injectable vaccines or high rates of vaccine hesitancy. Inhalable vaccines have the potential to address these distribution and compliance issues as they are less likely to require cold storage, avoid the use of needles, and can elicit localized immune responses with only a single dose. Alveolar macrophages represent attractive targets for inhalable vaccines as they are abundant within the lung mucosa (up to 95% of all immune cells) and are important mediators of mucosal immunity, and evidence suggests that they may be key cellular players in early Covid-19 pathogenesis. Here, we report inhalable coronavirus mimetic particles (CoMiP) designed to rapidly bind to, and be internalized by, alveolar macrophages to deliver nucleic acid-encoded viral antigens. Inspired by the SARS-CoV-2 virion structure, CoMiP carriers package nucleic acid cargo within an endosomolytic peptide envelope that is wrapped in a macrophage-targeting glycosaminoglycan coating. Through this design, CoMiP mimic several important features of the SARS-CoV-2 virion, particularly surface topography and macromolecular chemistry. As a result, CoMiP effect pleiotropic transfection of macrophages and lung epithelial cells in vitro with multiple antigen-encoding plasmids. In vivo immunization yields increased mucosal IgA levels within the respiratory tract of CoMiP vaccinated mice. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |Antigen Presentation[MESH] |COVID-19 Vaccines[MESH] |Mice[MESH]Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Pres(epmc).pdf DeepDyve Pubget Overpricing