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10.1007/s00018-022-04126-3 http://scihub22266oqcxt.onion/10.1007/s00018-022-04126-3 35079870!8788905!35079870     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35079870&cmd=llinks): Failed to open stream: HTTP request failed! 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Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives |pdf=|usr=}}{{35079870}} gab.com Text Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35079870 #FOAvip Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell through altering the structure and functions of proteins. The action of the most prevalent PTMs, encompassing phosphorylation, methylation, acylations, ubiquitination and glycosylation is well documented. A less explored protein PTM, conversion of peptidylarginine to citrulline, is the subject of this review. The process of citrullination is catalysed by peptidylarginine deiminases (PADs), a family of conserved enzymes expressed in a variety of human tissues. Accumulating evidence suggest that citrullination plays a significant role in regulating cellular metabolism and gene expression by affecting a multitude of pathways and modulating the chromatin status. Here, we will discuss the biochemical nature of arginine citrullination, the enzymatic machinery behind it and also provide information on the pathological consequences of citrullination in the development of inflammatory diseases (rheumatoid arthritis, multiple sclerosis, psoriasis, systemic lupus erythematosus, periodontitis and COVID-19), cancer and thromboembolism. Finally, developments on inhibitors against protein citrullination and recent clinical trials providing a promising therapeutic approach to inflammatory disease by targeting citrullination are discussed. Twit Text FOAVip Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35079870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35079870 #FOAvip English Wikipedia <ref>{{Cite pmid|35079870}}</ref> Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives #MMPMID35079870 Ciesielski O; Biesiekierska M; Panthu B; Soszynski M; Pirola L; Balcerczyk A Cell Mol Life Sci 2022[Jan]; 79 (2): 94 PMID35079870show ga Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell through altering the structure and functions of proteins. The action of the most prevalent PTMs, encompassing phosphorylation, methylation, acylations, ubiquitination and glycosylation is well documented. A less explored protein PTM, conversion of peptidylarginine to citrulline, is the subject of this review. The process of citrullination is catalysed by peptidylarginine deiminases (PADs), a family of conserved enzymes expressed in a variety of human tissues. Accumulating evidence suggest that citrullination plays a significant role in regulating cellular metabolism and gene expression by affecting a multitude of pathways and modulating the chromatin status. Here, we will discuss the biochemical nature of arginine citrullination, the enzymatic machinery behind it and also provide information on the pathological consequences of citrullination in the development of inflammatory diseases (rheumatoid arthritis, multiple sclerosis, psoriasis, systemic lupus erythematosus, periodontitis and COVID-19), cancer and thromboembolism. Finally, developments on inhibitors against protein citrullination and recent clinical trials providing a promising therapeutic approach to inflammatory disease by targeting citrullination are discussed. |Autoimmune Diseases/*pathology[MESH] |COVID-19/pathology[MESH] |Citrullination/*physiology[MESH] |Citrulline/biosynthesis[MESH] |Energy Metabolism/physiology[MESH] |Extracellular Traps/immunology[MESH] |Gene Expression Regulation/genetics[MESH] |Humans[MESH] |Inflammation/*pathology[MESH] |Neoplasms/pathology[MESH] |Protein Processing, Post-Translational/*physiology[MESH] |Protein-Arginine Deiminases/*metabolism[MESH] |SARS-CoV-2/immunology[MESH]Citrullination in the pathology of inflammatory and autoimmune disorde(epmc).pdf DeepDyve Pubget Overpricing