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10.1186/s13059-022-02605-1

http://scihub22266oqcxt.onion/10.1186/s13059-022-02605-1
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35073995!8784862!35073995
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suck abstract from ncbi


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pmid35073995      Genome+Biol 2022 ; 23 (1): 33
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  • IDEAS: individual level differential expression analysis for single-cell RNA-seq data #MMPMID35073995
  • Zhang M; Liu S; Miao Z; Han F; Gottardo R; Sun W
  • Genome Biol 2022[Jan]; 23 (1): 33 PMID35073995show ga
  • We consider an increasingly popular study design where single-cell RNA-seq data are collected from multiple individuals and the question of interest is to find genes that are differentially expressed between two groups of individuals. Towards this end, we propose a statistical method named IDEAS (individual level differential expression analysis for scRNA-seq). For each gene, IDEAS summarizes its expression in each individual by a distribution and then assesses whether these individual-specific distributions are different between two groups of individuals. We apply IDEAS to assess gene expression differences of autism patients versus controls and COVID-19 patients with mild versus severe symptoms.
  • |*Software[MESH]
  • |Autistic Disorder/*genetics/metabolism/pathology[MESH]
  • |COVID-19/*genetics/metabolism/pathology/virology[MESH]
  • |Case-Control Studies[MESH]
  • |Exome Sequencing[MESH]
  • |Gene Expression Profiling[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Microglia/metabolism/pathology[MESH]
  • |Nerve Tissue Proteins/classification/genetics/metabolism[MESH]
  • |SARS-CoV-2/pathogenicity[MESH]
  • |Sequence Analysis, RNA/*methods[MESH]
  • |Severity of Illness Index[MESH]


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