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10.1080/15548627.2021.2021496 http://scihub22266oqcxt.onion/10.1080/15548627.2021.2021496 35067165!9397439!35067165     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2022 ; 18 (9): 2246-2248 Nephropedia Template TP {{tp|p=35067165|t=2022. SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death |pdf=|usr=}}{{35067165}} gab.com Text SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=35067165 #FOAvip As the coronavirus disease 2019 (COVID-19) pandemic continues to wreak havoc, researchers around the globe are working together to understand how the responsible agent - severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) damages the respiratory system and other organs. Macroautophagy/autophagy is an innate immune response against viral infection and is known to be manipulated by positive-strand RNA viruses, including SARS-CoV-2. Nevertheless, the link between autophagic subversion and cell death or inflammation in COVID-19 remains unclear. Emerging evidence suggests that SARS-CoV-2 could trigger pyroptosis, a form of inflammatory programmed cell death characterized by the activation of inflammasomes and CASP1 (caspase 1) and the formation of transmembrane pores by GSDMD (gasdermin D). In this connection, autophagic flux impairment is a known activator of inflammasomes. This prompted us to investigate if SARS-CoV-2 could target autophagy to induce inflammasome-dependent pyroptosis in lung epithelial cells.Abbreviations: ATP6AP1: ATPase H+ transporting accessory protein 1; CASP1: caspase 1; COVID-19: coronavirus disease 2019; GSDMD: gasdermin D; IL1B: interleukin 1 beta; IL18: interleukin 18; KRT 18: keratin 18; NLRP3: NLR family pyrin domain containing 3; NOD: nucleotide oligomerization domain; NSP6: non-structural protein 6; TFEB: transcription factor EB; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. Twit Text FOAVip SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=35067165 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35067165 #FOAvip English Wikipedia <ref>{{Cite pmid|35067165}}</ref> SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death #MMPMID35067165 Sun X; Yu J; Wong SH; Chan MTV; Zhang L; Wu WKK Autophagy 2022[Sep]; 18 (9): 2246-2248 PMID35067165show ga As the coronavirus disease 2019 (COVID-19) pandemic continues to wreak havoc, researchers around the globe are working together to understand how the responsible agent - severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) damages the respiratory system and other organs. Macroautophagy/autophagy is an innate immune response against viral infection and is known to be manipulated by positive-strand RNA viruses, including SARS-CoV-2. Nevertheless, the link between autophagic subversion and cell death or inflammation in COVID-19 remains unclear. Emerging evidence suggests that SARS-CoV-2 could trigger pyroptosis, a form of inflammatory programmed cell death characterized by the activation of inflammasomes and CASP1 (caspase 1) and the formation of transmembrane pores by GSDMD (gasdermin D). In this connection, autophagic flux impairment is a known activator of inflammasomes. This prompted us to investigate if SARS-CoV-2 could target autophagy to induce inflammasome-dependent pyroptosis in lung epithelial cells.Abbreviations: ATP6AP1: ATPase H+ transporting accessory protein 1; CASP1: caspase 1; COVID-19: coronavirus disease 2019; GSDMD: gasdermin D; IL1B: interleukin 1 beta; IL18: interleukin 18; KRT 18: keratin 18; NLRP3: NLR family pyrin domain containing 3; NOD: nucleotide oligomerization domain; NSP6: non-structural protein 6; TFEB: transcription factor EB; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. |*COVID-19[MESH] |*Vacuolar Proton-Translocating ATPases/metabolism[MESH] |Autophagy[MESH] |Caspase 1/metabolism[MESH] |Humans[MESH] |Inflammasomes/metabolism[MESH] |Interleukin-1beta/metabolism[MESH] |Lung/metabolism[MESH] |Lysosomes/metabolism[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/metabolism[MESH] |Pyroptosis[MESH]SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell de(epmc).pdf DeepDyve Pubget Overpricing