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10.1186/s12979-022-00262-3 http://scihub22266oqcxt.onion/10.1186/s12979-022-00262-3 35065665!8783172!35065665     free     free     free       Immun+Ageing 2022 ; 19 (1): 6 Nephropedia Template TP {{tp|p=35065665|t=2022. What s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?|pdf=|usr=}}{{35065665}} gab.com Text What s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability JO: Immun Ageing http://www.kidney.de/pget.php?&tw=1&pmid=35065665 #FOAvip The present COVID-19 pandemic has revealed that several characteristics render patients especially prone to developing severe COVID-19 disease, i.e., the male sex, obesity, and old age. An explanation for the observed pattern of vulnerability has been proposed which is based on the concept of low sensitivity of the TLR7-signaling pathway at the time of infection as a common denominator of vulnerable patient groups.We will discuss whether the concept of established TLR-tolerance in macrophages and dendritic cells of the obese and elderly prior to infection can explain not only the vulnerability of these two demographic groups towards development of a severe infection with SARS-CoV-2, but also the observed cytokine response in these vulnerable patients, which is skewed towards pro-inflammatory cytokines with a missing interferon signature. Twit Text FOAVip What s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability ????Immun Ageing http://www.kidney.de/pget.php?&tw=1&pmid=35065665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35065665 #FOAvip English Wikipedia <ref>{{Cite pmid|35065665}}</ref> What s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability? #MMPMID35065665 Englmeier L; Subburayalu J Immun Ageing 2022[Jan]; 19 (1): 6 PMID35065665show ga The present COVID-19 pandemic has revealed that several characteristics render patients especially prone to developing severe COVID-19 disease, i.e., the male sex, obesity, and old age. An explanation for the observed pattern of vulnerability has been proposed which is based on the concept of low sensitivity of the TLR7-signaling pathway at the time of infection as a common denominator of vulnerable patient groups.We will discuss whether the concept of established TLR-tolerance in macrophages and dendritic cells of the obese and elderly prior to infection can explain not only the vulnerability of these two demographic groups towards development of a severe infection with SARS-CoV-2, but also the observed cytokine response in these vulnerable patients, which is skewed towards pro-inflammatory cytokines with a missing interferon signature. ?What s happening where when SARS-CoV-2 infects: are TLR7 and MAFB suff(epmc).pdf DeepDyve Pubget Overpricing