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  • Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link? #MMPMID35065613
  • Osei SA; Biney RP; Anning AS; Nortey LN; Ghartey-Kwansah G
  • BMC Infect Dis 2022[Jan]; 22 (1): 78 PMID35065613show ga
  • BACKGROUND: Despite reports of malaria and coronavirus diseases 2019 (COVID-19) co-infection, malaria-endemic regions have so far recorded fewer cases of COVID-19 and deaths from COVID-19, indicating a probable protection from the poor outcome of COVID-19 by malaria. On the contrary, other evidence suggests that malaria might contribute to the death caused by COVID-19. Hence, this paper reviewed existing evidence hypothesizing poor outcome or protection of COVID-19 patients when co-infected with malaria. METHODS: PRISMA guidelines for systematic review were employed in this study. Published articles from December 2019 to May 2021on COVID-19 and malaria co-infection and outcome were systematically searched in relevant and accessible databases following a pre-defined strategy. Studies involving human, in vivo animal studies, and in vitro studies were included. RESULTS: Twenty three (23) studies were included in the review out of the 3866 records identified in the selected scientific databases. Nine (9) papers reported on co-infection of COVID-19 and malaria. Five (5) papers provided information about synergism of malaria and COVID-19 poor prognosis, 2 papers reported on syndemic of COVID-19 and malaria intervention, and 7 studies indicated that malaria protects individuals from COVID-19. CONCLUSIONS: Low incidence of COVID-19 in malaria-endemic regions supports the hypothesis that COVID-19 poor prognosis is prevented by malaria. Although further studies are required to ascertain this hypothesis, cross-immunity and common immunodominant isotopes provide strong evidence to support this hypothesis. Also, increase in co-inhibitory receptors and atypical memory B cells indicate synergy between COVID-19 and malaria outcome, though, more studies are required to make a definite conclusion.
  • |*COVID-19[MESH]
  • |*Coinfection/epidemiology[MESH]
  • |*Malaria/complications/epidemiology[MESH]
  • |Africa/epidemiology[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Memory B Cells[MESH]
  • |SARS-CoV-2[MESH]

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  • suck abstract from ncbi

    78 1.22 2022