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10.1038/s41467-021-27716-4 http://scihub22266oqcxt.onion/10.1038/s41467-021-27716-4 35064122!8782894!35064122     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35064122&cmd=llinks): Failed to open stream: HTTP request failed! 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Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 |pdf=|usr=}}{{35064122}} gab.com Text Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35064122 #FOAvip Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology are poorly understood. Here we use multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab. Coordinated profiling of gene expression and cell lineage protein markers shows that S100A(hi)/HLA-DR(lo) classical monocytes and activated LAG-3(hi) T cells are hallmarks of progressive disease and highlights the abnormal MHC-II/LAG-3 interaction on myeloid and T cells, respectively. We also find skewed T cell receptor repertories in expanded effector CD8(+) clones, unmutated IGHG(+) B cell clones, and mutated B cell clones with stable somatic hypermutation frequency over time. In conclusion, our in-depth immune profiling reveals dyssynchrony of the innate and adaptive immune interaction in progressive COVID-19. Twit Text FOAVip Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35064122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35064122 #FOAvip English Wikipedia <ref>{{Cite pmid|35064122}}</ref> Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 #MMPMID35064122 Unterman A; Sumida TS; Nouri N; Yan X; Zhao AY; Gasque V; Schupp JC; Asashima H; Liu Y; Cosme C Jr; Deng W; Chen M; Raredon MSB; Hoehn KB; Wang G; Wang Z; DeIuliis G; Ravindra NG; Li N; Castaldi C; Wong P; Fournier J; Bermejo S; Sharma L; Casanovas-Massana A; Vogels CBF; Wyllie AL; Grubaugh ND; Melillo A; Meng H; Stein Y; Minasyan M; Mohanty S; Ruff WE; Cohen I; Raddassi K; Niklason LE; Ko AI; Montgomery RR; Farhadian SF; Iwasaki A; Shaw AC; van Dijk D; Zhao H; Kleinstein SH; Hafler DA; Kaminski N; Dela Cruz CS Nat Commun 2022[Jan]; 13 (1): 440 PMID35064122show ga Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology are poorly understood. Here we use multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab. Coordinated profiling of gene expression and cell lineage protein markers shows that S100A(hi)/HLA-DR(lo) classical monocytes and activated LAG-3(hi) T cells are hallmarks of progressive disease and highlights the abnormal MHC-II/LAG-3 interaction on myeloid and T cells, respectively. We also find skewed T cell receptor repertories in expanded effector CD8(+) clones, unmutated IGHG(+) B cell clones, and mutated B cell clones with stable somatic hypermutation frequency over time. In conclusion, our in-depth immune profiling reveals dyssynchrony of the innate and adaptive immune interaction in progressive COVID-19. |Adaptive Immunity/drug effects/genetics/*immunology[MESH] |Aged[MESH] |Antibodies, Monoclonal, Humanized/therapeutic use[MESH] |CD4-Positive T-Lymphocytes/drug effects/immunology/metabolism[MESH] |CD8-Positive T-Lymphocytes/drug effects/immunology/metabolism[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/genetics/*immunology[MESH] |Cells, Cultured[MESH] |Female[MESH] |Gene Expression Profiling/*methods[MESH] |Gene Expression Regulation/drug effects/immunology[MESH] |Humans[MESH] |Immunity, Innate/drug effects/genetics/*immunology[MESH] |Male[MESH] |RNA-Seq/methods[MESH] |Receptors, Antigen, B-Cell/genetics/immunology[MESH] |Receptors, Antigen, T-Cell/genetics/immunology[MESH] |SARS-CoV-2/drug effects/*immunology/physiology[MESH]Single-cell multi-omics reveals dyssynchrony of the innate and adaptiv(epmc).pdf DeepDyve Pubget Overpricing