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10.1016/j.arr.2022.101571

http://scihub22266oqcxt.onion/10.1016/j.arr.2022.101571
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35063697!ä!35063697

suck abstract from ncbi


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pmid35063697      Ageing+Res+Rev 2022 ; 75 (ä): 101571
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  • Do Vitamin D receptor gene polymorphisms affect bone mass density in men?: A meta-analysis of observational studies #MMPMID35063697
  • Pakpahan C; Wungu CDK; Agustinus A; Darmadi D
  • Ageing Res Rev 2022[Mar]; 75 (ä): 101571 PMID35063697show ga
  • The signs of aging in humans can often be detected through a decrease in bone mass density (BMD). The decrease in BMD as a risk of osteoporosis is often only seen in women, but not in men, even though men also have a risk of osteoporosis which can affect their well-being. We conducted study searches through databases such as PubMed, EBSCO, ProQuest, Willey Online, Science Direct, and SAGE. We performed analysis on four types of Vitamin D receptor polymorphisms: BsmI, ApaI, FokI, and TaqI from 14 potential studies involving men. We found that several genetic analysis models of BsmI and FokI significantly affected BMD in men: BB vs bb in whole body BMD (SMD = 0.43, 95% CI = [0.12-0.75], p = 0.0008, BB vs Bb in whole body BMD (SMD = -1.38, 95% CI = [-1.87 to 0.88], p < 0.00001), and FF+Ff vs ff spine BMD (SMD = 0.59, 95% CI = 0.13-1.05], p = 0.001), even after adjusting for comorbidities as confounding variables. The present meta-analysis showed that BsmI and FokI polymorphisms of the VDR gene were correlated with decreased BMD in men which may contribute to the aging process and well-being.
  • |*Bone Density/genetics[MESH]
  • |*Osteoporosis/genetics[MESH]
  • |*Receptors, Calcitriol/genetics[MESH]
  • |Female[MESH]
  • |Genetic Predisposition to Disease[MESH]
  • |Genotype[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Observational Studies as Topic[MESH]


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