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10.1016/j.stemcr.2021.12.011 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2021.12.011 35063125!8772030!35063125     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2022 ; 17 (2): 307-320 Nephropedia Template TP {{tp|p=35063125|t=2022. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 |pdf=|usr=}}{{35063125}} gab.com Text The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=35063125 #FOAvip Neurological complications are common in COVID-19. Although SARS-CoV-2 has been detected in patients' brain tissues, its entry routes and resulting consequences are not well understood. Here, we show a pronounced upregulation of interferon signaling pathways of the neurovascular unit in fatal COVID-19. By investigating the susceptibility of human induced pluripotent stem cell (hiPSC)-derived brain capillary endothelial-like cells (BCECs) to SARS-CoV-2 infection, we found that BCECs were infected and recapitulated transcriptional changes detected in vivo. While BCECs were not compromised in their paracellular tightness, we found SARS-CoV-2 in the basolateral compartment in transwell assays after apical infection, suggesting active replication and transcellular transport of virus across the blood-brain barrier (BBB) in vitro. Moreover, entry of SARS-CoV-2 into BCECs could be reduced by anti-spike-, anti-angiotensin-converting enzyme 2 (ACE2)-, and anti-neuropilin-1 (NRP1)-specific antibodies or the transmembrane protease serine subtype 2 (TMPRSS2) inhibitor nafamostat. Together, our data provide strong support for SARS-CoV-2 brain entry across the BBB resulting in increased interferon signaling. Twit Text FOAVip The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=35063125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35063125 #FOAvip English Wikipedia <ref>{{Cite pmid|35063125}}</ref> The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 #MMPMID35063125 Krasemann S; Haferkamp U; Pfefferle S; Woo MS; Heinrich F; Schweizer M; Appelt-Menzel A; Cubukova A; Barenberg J; Leu J; Hartmann K; Thies E; Littau JL; Sepulveda-Falla D; Zhang L; Ton K; Liang Y; Matschke J; Ricklefs F; Sauvigny T; Sperhake J; Fitzek A; Gerhartl A; Brachner A; Geiger N; Konig EM; Bodem J; Franzenburg S; Franke A; Moese S; Muller FJ; Geisslinger G; Claussen C; Kannt A; Zaliani A; Gribbon P; Ondruschka B; Neuhaus W; Friese MA; Glatzel M; Pless O Stem Cell Reports 2022[Feb]; 17 (2): 307-320 PMID35063125show ga Neurological complications are common in COVID-19. Although SARS-CoV-2 has been detected in patients' brain tissues, its entry routes and resulting consequences are not well understood. Here, we show a pronounced upregulation of interferon signaling pathways of the neurovascular unit in fatal COVID-19. By investigating the susceptibility of human induced pluripotent stem cell (hiPSC)-derived brain capillary endothelial-like cells (BCECs) to SARS-CoV-2 infection, we found that BCECs were infected and recapitulated transcriptional changes detected in vivo. While BCECs were not compromised in their paracellular tightness, we found SARS-CoV-2 in the basolateral compartment in transwell assays after apical infection, suggesting active replication and transcellular transport of virus across the blood-brain barrier (BBB) in vitro. Moreover, entry of SARS-CoV-2 into BCECs could be reduced by anti-spike-, anti-angiotensin-converting enzyme 2 (ACE2)-, and anti-neuropilin-1 (NRP1)-specific antibodies or the transmembrane protease serine subtype 2 (TMPRSS2) inhibitor nafamostat. Together, our data provide strong support for SARS-CoV-2 brain entry across the BBB resulting in increased interferon signaling. |*Virus Internalization/drug effects[MESH] |Antibodies/pharmacology[MESH] |Benzamidines/pharmacology[MESH] |Blood-Brain Barrier/*virology[MESH] |COVID-19/pathology/virology[MESH] |Central Nervous System/*virology[MESH] |Endothelial Cells/cytology/metabolism/virology[MESH] |Guanidines/pharmacology[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/cytology/metabolism[MESH] |Models, Biological[MESH] |RNA, Viral/metabolism[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH]The blood-brain barrier is dysregulated in COVID-19 and serves as a CN(epmc).pdf DeepDyve Pubget Overpricing