Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.str.2021.12.011 http://scihub22266oqcxt.onion/10.1016/j.str.2021.12.011 35063064!8772014!35063064     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Structure 2022 ; 30 (4): 590-607.e4 Nephropedia Template TP {{tp|p=35063064|t=2022. Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein |pdf=|usr=}}{{35063064}} gab.com Text Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein JO: Structure http://www.kidney.de/pget.php?&tw=1&pmid=35063064 #FOAvip Recent developments in the SARS-CoV-2 pandemic point to its inevitable transformation into an endemic disease, urging both refinement of diagnostics for emerging variants of concern (VOCs) and design of variant-specific drugs in addition to vaccine adjustments. Exploring the structure and dynamics of the SARS-CoV-2 Spike protein, we argue that the high-mutability characteristic of RNA viruses coupled with the remarkable flexibility and dynamics of viral proteins result in a substantial involvement of allosteric mechanisms. While allosteric effects of mutations should be considered in predictions and diagnostics of new VOCs, allosteric drugs advantageously avoid escape mutations via non-competitive inhibition originating from alternative distal locations. The exhaustive allosteric signaling and probing maps presented herein provide a comprehensive picture of allostery in the spike protein, making it possible to locate potential mutations that could work as new VOC "drivers" and to determine binding patches that may be targeted by newly developed allosteric drugs. Twit Text FOAVip Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein ????Structure http://www.kidney.de/pget.php?&tw=1&pmid=35063064 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35063064 #FOAvip English Wikipedia <ref>{{Cite pmid|35063064}}</ref> Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein #MMPMID35063064 Tan ZW; Tee WV; Samsudin F; Guarnera E; Bond PJ; Berezovsky IN Structure 2022[Apr]; 30 (4): 590-607.e4 PMID35063064show ga Recent developments in the SARS-CoV-2 pandemic point to its inevitable transformation into an endemic disease, urging both refinement of diagnostics for emerging variants of concern (VOCs) and design of variant-specific drugs in addition to vaccine adjustments. Exploring the structure and dynamics of the SARS-CoV-2 Spike protein, we argue that the high-mutability characteristic of RNA viruses coupled with the remarkable flexibility and dynamics of viral proteins result in a substantial involvement of allosteric mechanisms. While allosteric effects of mutations should be considered in predictions and diagnostics of new VOCs, allosteric drugs advantageously avoid escape mutations via non-competitive inhibition originating from alternative distal locations. The exhaustive allosteric signaling and probing maps presented herein provide a comprehensive picture of allostery in the spike protein, making it possible to locate potential mutations that could work as new VOC "drivers" and to determine binding patches that may be targeted by newly developed allosteric drugs. |*COVID-19 Drug Treatment[MESH] |*Spike Glycoprotein, Coronavirus/chemistry/genetics[MESH] |Humans[MESH] |Mutation[MESH] |Pandemics[MESH]Allosteric perspective on the mutability and druggability of the SARS-(epmc).pdf DeepDyve Pubget Overpricing